| http://purl.uniprot.org/citations/18697906 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18697906 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18697906 | http://www.w3.org/2000/01/rdf-schema#comment | "We identify Balpha (PPP2R2A) and Bdelta (PPP2R2D), two highly related members of the B family of regulatory subunits of the protein phosphatase PP2A, as important modulators of TGF-beta/Activin/Nodal signalling that affect the pathway in opposite ways. Knockdown of Balpha in Xenopus embryos or mammalian tissue culture cells suppresses TGF-beta/Activin/Nodal-dependent responses, whereas knockdown of Bdelta enhances these responses. Moreover, in Drosophila, overexpression of Smad2 rescues a severe wing phenotype caused by overexpression of the single Drosophila PP2A B subunit Twins. We show that, in vertebrates, Balpha enhances TGF-beta/Activin/Nodal signalling by stabilising the basal levels of type I receptor, whereas Bdelta negatively modulates these pathways by restricting receptor activity. Thus, these highly related members of the same subfamily of PP2A regulatory subunits differentially regulate TGF-beta/Activin/Nodal signalling to elicit opposing biological outcomes."xsd:string |
| http://purl.uniprot.org/citations/18697906 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.020842"xsd:string |
| http://purl.uniprot.org/citations/18697906 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.020842"xsd:string |
| http://purl.uniprot.org/citations/18697906 | http://purl.uniprot.org/core/author | "Batut J."xsd:string |
| http://purl.uniprot.org/citations/18697906 | http://purl.uniprot.org/core/author | "Batut J."xsd:string |
| http://purl.uniprot.org/citations/18697906 | http://purl.uniprot.org/core/author | "Cao J."xsd:string |
| http://purl.uniprot.org/citations/18697906 | http://purl.uniprot.org/core/author | "Cao J."xsd:string |
| http://purl.uniprot.org/citations/18697906 | http://purl.uniprot.org/core/author | "Hill C.S."xsd:string |
| http://purl.uniprot.org/citations/18697906 | http://purl.uniprot.org/core/author | "Hill C.S."xsd:string |
| http://purl.uniprot.org/citations/18697906 | http://purl.uniprot.org/core/author | "Howell M."xsd:string |
| http://purl.uniprot.org/citations/18697906 | http://purl.uniprot.org/core/author | "Howell M."xsd:string |
| http://purl.uniprot.org/citations/18697906 | http://purl.uniprot.org/core/author | "Raftery L.A."xsd:string |
| http://purl.uniprot.org/citations/18697906 | http://purl.uniprot.org/core/author | "Raftery L.A."xsd:string |
| http://purl.uniprot.org/citations/18697906 | http://purl.uniprot.org/core/author | "Schmierer B."xsd:string |
| http://purl.uniprot.org/citations/18697906 | http://purl.uniprot.org/core/author | "Schmierer B."xsd:string |
| http://purl.uniprot.org/citations/18697906 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18697906 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18697906 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/18697906 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/18697906 | http://purl.uniprot.org/core/pages | "2927-2937"xsd:string |
| http://purl.uniprot.org/citations/18697906 | http://purl.uniprot.org/core/pages | "2927-2937"xsd:string |
| http://purl.uniprot.org/citations/18697906 | http://purl.uniprot.org/core/title | "Two highly related regulatory subunits of PP2A exert opposite effects on TGF-beta/Activin/Nodal signalling."xsd:string |
| http://purl.uniprot.org/citations/18697906 | http://purl.uniprot.org/core/title | "Two highly related regulatory subunits of PP2A exert opposite effects on TGF-beta/Activin/Nodal signalling."xsd:string |