| http://purl.uniprot.org/citations/18701065 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18701065 | http://www.w3.org/2000/01/rdf-schema#comment | "In the mammalian central nervous system, slow synaptic excitation involves the activation of metabotropic glutamate receptors (mGluRs). It has been proposed that C1-type transient receptor potential (TRPC1) channels underlie this synaptic excitation, but our analysis of TRPC1-deficient mice does not support this hypothesis. Here, we show unambiguously that it is TRPC3 that is needed for mGluR-dependent synaptic signaling in mouse cerebellar Purkinje cells. TRPC3 is the most abundantly expressed TRPC subunit in Purkinje cells. In mutant mice lacking TRPC3, both slow synaptic potentials and mGluR-mediated inward currents are completely absent, while the synaptically mediated Ca2+ release signals from intracellular stores are unchanged. Importantly, TRPC3 knockout mice exhibit an impaired walking behavior. Taken together, our results establish TRPC3 as a new type of postsynaptic channel that mediates mGluR-dependent synaptic transmission in cerebellar Purkinje cells and is crucial for motor coordination."xsd:string |
| http://purl.uniprot.org/citations/18701065 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2008.06.009"xsd:string |
| http://purl.uniprot.org/citations/18701065 | http://purl.uniprot.org/core/author | "Birnbaumer L."xsd:string |
| http://purl.uniprot.org/citations/18701065 | http://purl.uniprot.org/core/author | "Hartmann J."xsd:string |
| http://purl.uniprot.org/citations/18701065 | http://purl.uniprot.org/core/author | "Abramowitz J."xsd:string |
| http://purl.uniprot.org/citations/18701065 | http://purl.uniprot.org/core/author | "Flockerzi V."xsd:string |
| http://purl.uniprot.org/citations/18701065 | http://purl.uniprot.org/core/author | "Freichel M."xsd:string |
| http://purl.uniprot.org/citations/18701065 | http://purl.uniprot.org/core/author | "Dietrich A."xsd:string |
| http://purl.uniprot.org/citations/18701065 | http://purl.uniprot.org/core/author | "Blum R."xsd:string |
| http://purl.uniprot.org/citations/18701065 | http://purl.uniprot.org/core/author | "Adelsberger H."xsd:string |
| http://purl.uniprot.org/citations/18701065 | http://purl.uniprot.org/core/author | "Konnerth A."xsd:string |
| http://purl.uniprot.org/citations/18701065 | http://purl.uniprot.org/core/author | "Dragicevic E."xsd:string |
| http://purl.uniprot.org/citations/18701065 | http://purl.uniprot.org/core/author | "Henning H.A."xsd:string |
| http://purl.uniprot.org/citations/18701065 | http://purl.uniprot.org/core/author | "Sumser M."xsd:string |
| http://purl.uniprot.org/citations/18701065 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18701065 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/18701065 | http://purl.uniprot.org/core/pages | "392-398"xsd:string |
| http://purl.uniprot.org/citations/18701065 | http://purl.uniprot.org/core/title | "TRPC3 channels are required for synaptic transmission and motor coordination."xsd:string |
| http://purl.uniprot.org/citations/18701065 | http://purl.uniprot.org/core/volume | "59"xsd:string |
| http://purl.uniprot.org/citations/18701065 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18701065 |
| http://purl.uniprot.org/citations/18701065 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18701065 |
| http://purl.uniprot.org/uniprot/#_A0A087WP07-mappedCitation-18701065 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18701065 |
| http://purl.uniprot.org/uniprot/#_A0A087WSD0-mappedCitation-18701065 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18701065 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JEV6-mappedCitation-18701065 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18701065 |