| http://purl.uniprot.org/citations/18701069 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18701069 | http://www.w3.org/2000/01/rdf-schema#comment | "Small-conductance Ca2+-activated K+ (SK) channels are widely expressed in neuronal tissues where they underlie post-spike hyperpolarizations, regulate spike-frequency adaptation, and shape synaptic responses. SK channels constitutively interact with calmodulin (CaM), which serves as Ca2+ sensor, and with protein kinase CK2 and protein phosphatase 2A, which modulate their Ca2+ gating. By recording coupled activities of Ca2+ and SK2 channels, we showed that SK2 channels can be inhibited by neurotransmitters independently of changes in the activity of the priming Ca2+ channels. This inhibition involvesSK2-associated CK2 and results from a 3-fold reduction in the Ca2+ sensitivity of channel gating. CK2phosphorylated SK2-bound CaM but not KCNQ2-bound CaM, thereby selectively regulating SK2 channels. We extended these observations to sensory neurons by showing that noradrenaline inhibits SK current and increases neuronal excitability in aCK2-dependent fashion. Hence, neurotransmitter-initiated signaling cascades can dynamically regulate Ca2+ sensitivity of SK channels and directly influence somatic excitability."xsd:string |
| http://purl.uniprot.org/citations/18701069 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2008.05.026"xsd:string |
| http://purl.uniprot.org/citations/18701069 | http://purl.uniprot.org/core/author | "Hao J."xsd:string |
| http://purl.uniprot.org/citations/18701069 | http://purl.uniprot.org/core/author | "Adelman J.P."xsd:string |
| http://purl.uniprot.org/citations/18701069 | http://purl.uniprot.org/core/author | "Delmas P."xsd:string |
| http://purl.uniprot.org/citations/18701069 | http://purl.uniprot.org/core/author | "Allen D."xsd:string |
| http://purl.uniprot.org/citations/18701069 | http://purl.uniprot.org/core/author | "Litchfield D.W."xsd:string |
| http://purl.uniprot.org/citations/18701069 | http://purl.uniprot.org/core/author | "Crest M."xsd:string |
| http://purl.uniprot.org/citations/18701069 | http://purl.uniprot.org/core/author | "Maingret F."xsd:string |
| http://purl.uniprot.org/citations/18701069 | http://purl.uniprot.org/core/author | "Coste B."xsd:string |
| http://purl.uniprot.org/citations/18701069 | http://purl.uniprot.org/core/author | "Giamarchi A."xsd:string |
| http://purl.uniprot.org/citations/18701069 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18701069 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/18701069 | http://purl.uniprot.org/core/pages | "439-449"xsd:string |
| http://purl.uniprot.org/citations/18701069 | http://purl.uniprot.org/core/title | "Neurotransmitter modulation of small-conductance Ca2+-activated K+ channels by regulation of Ca2+ gating."xsd:string |
| http://purl.uniprot.org/citations/18701069 | http://purl.uniprot.org/core/volume | "59"xsd:string |
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