| http://purl.uniprot.org/citations/18706403 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18706403 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18706403 | http://www.w3.org/2000/01/rdf-schema#comment | "The Caenorhabditis elegans gene hlh-6 is expressed specifically in pharyngeal glands, one of five distinct pharyngeal cell types. Expression of hlh-6 is controlled by a discrete set of cis-regulatory elements, including a negative element called HRL1. Here we demonstrate that HRL1 is a functional binding site for LAG-1, the CSL transcriptional effector of Notch in C. elegans, and that regulation of hlh-6 by LAG-1 is direct. Regulation of hlh-6 by LAG-1 is strictly negative: removal of HRL1 or LAG-1 regulation results in ectopic expression of hlh-6, but does not affect expression in pharyngeal glands. Furthermore, direct regulation of hlh-6 expression does not appear to involve Notch signaling, contrary to the canonical mechanism by which CSL factors regulate target genes. We also identify an additional cis-regulatory element in the hlh-6 promoter that, together with previously identified elements, is sufficient to overcome repression by LAG-1 and activate hlh-6 expression in pharyngeal glands."xsd:string |
| http://purl.uniprot.org/citations/18706403 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ydbio.2008.07.018"xsd:string |
| http://purl.uniprot.org/citations/18706403 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ydbio.2008.07.018"xsd:string |
| http://purl.uniprot.org/citations/18706403 | http://purl.uniprot.org/core/author | "Gaudet J."xsd:string |
| http://purl.uniprot.org/citations/18706403 | http://purl.uniprot.org/core/author | "Gaudet J."xsd:string |
| http://purl.uniprot.org/citations/18706403 | http://purl.uniprot.org/core/author | "Ghai V."xsd:string |
| http://purl.uniprot.org/citations/18706403 | http://purl.uniprot.org/core/author | "Ghai V."xsd:string |
| http://purl.uniprot.org/citations/18706403 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18706403 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18706403 | http://purl.uniprot.org/core/name | "Dev. Biol."xsd:string |
| http://purl.uniprot.org/citations/18706403 | http://purl.uniprot.org/core/name | "Dev. Biol."xsd:string |
| http://purl.uniprot.org/citations/18706403 | http://purl.uniprot.org/core/pages | "334-344"xsd:string |
| http://purl.uniprot.org/citations/18706403 | http://purl.uniprot.org/core/pages | "334-344"xsd:string |
| http://purl.uniprot.org/citations/18706403 | http://purl.uniprot.org/core/title | "The CSL transcription factor LAG-1 directly represses hlh-6 expression in C. elegans."xsd:string |
| http://purl.uniprot.org/citations/18706403 | http://purl.uniprot.org/core/title | "The CSL transcription factor LAG-1 directly represses hlh-6 expression in C. elegans."xsd:string |
| http://purl.uniprot.org/citations/18706403 | http://purl.uniprot.org/core/volume | "322"xsd:string |
| http://purl.uniprot.org/citations/18706403 | http://purl.uniprot.org/core/volume | "322"xsd:string |
| http://purl.uniprot.org/citations/18706403 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18706403 |
| http://purl.uniprot.org/citations/18706403 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18706403 |
| http://purl.uniprot.org/citations/18706403 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18706403 |
| http://purl.uniprot.org/citations/18706403 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18706403 |
| http://purl.uniprot.org/uniprot/V6CLJ5 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/18706403 |
| http://purl.uniprot.org/uniprot/Q10651#attribution-0BBF8CD60884A1A644B538335D6C3877 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18706403 |