| http://purl.uniprot.org/citations/18714023 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18714023 | http://www.w3.org/2000/01/rdf-schema#comment | "The transcription factor NF-kappaB plays a pivotal role in regulating inflammatory gene expression. Its effects are optimized by various coactivators, including histone acetyltransferases (HATs) such as CREB-binding protein/p300 and p300/CBP-associated factor (p/CAF). The molecular mechanisms regulating cofactor recruitment are poorly understood. In this study, we describe a novel role for protein kinase C (PKC) betaIotaIota in augmenting NF-kappaB-mediated TNF-alpha-induced transcription of the target gene CCL11 in human airway smooth muscle cells by phosphorylating the HAT p/CAF. Studies using reporters, overexpression strategies, kinase-dead and HAT-defective mutants, and chromatin immunoprecipitation showed that PKCbetaII activation was not involved in NF-kappaB translocation, but facilitated NF-kappaB-mediated CCL11 transcription by colocalizing with and phosphorylating p/CAF, and thereby acetylating histone H4 and promoting p65 association with the CCL11 promoter. The effect was dependent on p/CAF's HAT activity. Furthermore, mouse embryonic fibroblasts from PKCbeta knockout mice showed markedly reduced TNF-alpha-induced CCL11 expression and NF-kappaB reporter activity that was restored on PKCbetaII overexpression, suggesting a critical role for this pathway. These data suggest a novel important biological role for PKCbetaIotaIota in NF-kappaB-mediated CCL11 transcription by p/CAF activation and histone H4 acetylation."xsd:string |
| http://purl.uniprot.org/citations/18714023 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.181.5.3503"xsd:string |
| http://purl.uniprot.org/citations/18714023 | http://purl.uniprot.org/core/author | "Sutcliffe A."xsd:string |
| http://purl.uniprot.org/citations/18714023 | http://purl.uniprot.org/core/author | "Clarke D.L."xsd:string |
| http://purl.uniprot.org/citations/18714023 | http://purl.uniprot.org/core/author | "Deacon K."xsd:string |
| http://purl.uniprot.org/citations/18714023 | http://purl.uniprot.org/core/author | "Knox A.J."xsd:string |
| http://purl.uniprot.org/citations/18714023 | http://purl.uniprot.org/core/author | "Corbett L."xsd:string |
| http://purl.uniprot.org/citations/18714023 | http://purl.uniprot.org/core/author | "Bradbury D."xsd:string |
| http://purl.uniprot.org/citations/18714023 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18714023 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/18714023 | http://purl.uniprot.org/core/pages | "3503-3514"xsd:string |
| http://purl.uniprot.org/citations/18714023 | http://purl.uniprot.org/core/title | "PKCbetaII augments NF-kappaB-dependent transcription at the CCL11 promoter via p300/CBP-associated factor recruitment and histone H4 acetylation."xsd:string |
| http://purl.uniprot.org/citations/18714023 | http://purl.uniprot.org/core/volume | "181"xsd:string |
| http://purl.uniprot.org/citations/18714023 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18714023 |
| http://purl.uniprot.org/citations/18714023 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18714023 |
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| http://purl.uniprot.org/uniprot/#_B4E082-mappedCitation-18714023 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18714023 |
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| http://purl.uniprot.org/uniprot/#_P51671-mappedCitation-18714023 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18714023 |
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| http://purl.uniprot.org/uniprot/#_P78359-mappedCitation-18714023 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18714023 |