| http://purl.uniprot.org/citations/18714025 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18714025 | http://www.w3.org/2000/01/rdf-schema#comment | "The statins, a group of inhibitors of the 3-hydroxy-3-methylglutaryl coenzyme A reductase, are reported to influence a variety of immune system activities through 3-hydroxy-3-methylglutaryl coenzyme A reductase-dependent and -independent mechanisms. How statin treatment regulates immune system function in vivo nonetheless remains to be fully defined. We analyzed the immunomodulatory effects of lovastatin in a Candida albicans-induced delayed-type hypersensitivity reaction in mice. In this model, lovastatin administration reduced the acute inflammatory response elicited by C. albicans challenge. This anti-inflammatory activity of lovastatin was associated with a shift from a Th1 to a Th2 immune response, as well as an increase in the percentage of regulatory T cells at the inflammation site and in the regional draining lymph node. The lovastatin-induced increase in regulatory T cells in the inflamed skin was dependent on expression of CCL1, a chemokine that is locally up-regulated by statin administration. The anti-inflammatory effect of lovastatin was abrogated in CCL1-deficient mice. These results suggest that local regulation of chemokine expression may be an important process in statin-induced modulation of the immune system."xsd:string |
| http://purl.uniprot.org/citations/18714025 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.181.5.3524"xsd:string |
| http://purl.uniprot.org/citations/18714025 | http://purl.uniprot.org/core/author | "Martinez-A C."xsd:string |
| http://purl.uniprot.org/citations/18714025 | http://purl.uniprot.org/core/author | "Marquez G."xsd:string |
| http://purl.uniprot.org/citations/18714025 | http://purl.uniprot.org/core/author | "Zaballos A."xsd:string |
| http://purl.uniprot.org/citations/18714025 | http://purl.uniprot.org/core/author | "Ardavin C."xsd:string |
| http://purl.uniprot.org/citations/18714025 | http://purl.uniprot.org/core/author | "Goya I."xsd:string |
| http://purl.uniprot.org/citations/18714025 | http://purl.uniprot.org/core/author | "Stein J.V."xsd:string |
| http://purl.uniprot.org/citations/18714025 | http://purl.uniprot.org/core/author | "Manes S."xsd:string |
| http://purl.uniprot.org/citations/18714025 | http://purl.uniprot.org/core/author | "Barber D.F."xsd:string |
| http://purl.uniprot.org/citations/18714025 | http://purl.uniprot.org/core/author | "Leon B."xsd:string |
| http://purl.uniprot.org/citations/18714025 | http://purl.uniprot.org/core/author | "Almonacid L."xsd:string |
| http://purl.uniprot.org/citations/18714025 | http://purl.uniprot.org/core/author | "Mira E."xsd:string |
| http://purl.uniprot.org/citations/18714025 | http://purl.uniprot.org/core/author | "Jimenez-Baranda S."xsd:string |
| http://purl.uniprot.org/citations/18714025 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18714025 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/18714025 | http://purl.uniprot.org/core/pages | "3524-3534"xsd:string |
| http://purl.uniprot.org/citations/18714025 | http://purl.uniprot.org/core/title | "Statins induce regulatory T cell recruitment via a CCL1 dependent pathway."xsd:string |
| http://purl.uniprot.org/citations/18714025 | http://purl.uniprot.org/core/volume | "181"xsd:string |
| http://purl.uniprot.org/citations/18714025 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18714025 |
| http://purl.uniprot.org/citations/18714025 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18714025 |
| http://purl.uniprot.org/uniprot/#_Q0VB35-mappedCitation-18714025 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18714025 |
| http://purl.uniprot.org/uniprot/#_B1AVL8-mappedCitation-18714025 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18714025 |
| http://purl.uniprot.org/uniprot/#_P10146-mappedCitation-18714025 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18714025 |