| http://purl.uniprot.org/citations/18718448 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18718448 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18718448 | http://www.w3.org/2000/01/rdf-schema#comment | "The hematopoietic-specific transcription factor p45/NF-E2 is an important transcriptional activator in the erythroid and megakaryocytic lineages. We describe the first in vivo evidence for the interaction between p45/NF-E2 and the E3 ubiquitin ligase Itch, and the subsequent ubiquitination of p45/NF-E2 by Itch. Interestingly, Itch suppressed the transactivation activity of p45/NF-E2 by adding a Lys63-linked polyubiquitin chain. Confocal microscopy revealed that ubiquitinated p45/NF-E2 became localized in the cytoplasm when Itch was over-expressed. Thus, Itch-mediated ubiquitination of p45/NF-E2 does not target the protein for proteasomal degradation, but instead retains p45/NF-E2 in the cytoplasm, where it cannot function as a transactivator. Finally, we suggest that this Itch-dependent p45/NF-E2 ubiquitination mechanism may regulate NF-E2 function during the development of hematopoietic cell lineages."xsd:string |
| http://purl.uniprot.org/citations/18718448 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2008.07.164"xsd:string |
| http://purl.uniprot.org/citations/18718448 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2008.07.164"xsd:string |
| http://purl.uniprot.org/citations/18718448 | http://purl.uniprot.org/core/author | "Lee T.-L."xsd:string |
| http://purl.uniprot.org/citations/18718448 | http://purl.uniprot.org/core/author | "Lee T.-L."xsd:string |
| http://purl.uniprot.org/citations/18718448 | http://purl.uniprot.org/core/author | "Shen C.-K.J."xsd:string |
| http://purl.uniprot.org/citations/18718448 | http://purl.uniprot.org/core/author | "Shen C.-K.J."xsd:string |
| http://purl.uniprot.org/citations/18718448 | http://purl.uniprot.org/core/author | "Hsu T.-Y."xsd:string |
| http://purl.uniprot.org/citations/18718448 | http://purl.uniprot.org/core/author | "Hsu T.-Y."xsd:string |
| http://purl.uniprot.org/citations/18718448 | http://purl.uniprot.org/core/author | "Shyu Y.-C."xsd:string |
| http://purl.uniprot.org/citations/18718448 | http://purl.uniprot.org/core/author | "Shyu Y.-C."xsd:string |
| http://purl.uniprot.org/citations/18718448 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18718448 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18718448 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/18718448 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/18718448 | http://purl.uniprot.org/core/pages | "326-330"xsd:string |
| http://purl.uniprot.org/citations/18718448 | http://purl.uniprot.org/core/pages | "326-330"xsd:string |
| http://purl.uniprot.org/citations/18718448 | http://purl.uniprot.org/core/title | "Itch regulates p45/NF-E2 in vivo by Lys63-linked ubiquitination."xsd:string |
| http://purl.uniprot.org/citations/18718448 | http://purl.uniprot.org/core/title | "Itch regulates p45/NF-E2 in vivo by Lys63-linked ubiquitination."xsd:string |
| http://purl.uniprot.org/citations/18718448 | http://purl.uniprot.org/core/volume | "375"xsd:string |
| http://purl.uniprot.org/citations/18718448 | http://purl.uniprot.org/core/volume | "375"xsd:string |
| http://purl.uniprot.org/citations/18718448 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18718448 |
| http://purl.uniprot.org/citations/18718448 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18718448 |