| http://purl.uniprot.org/citations/18719102 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18719102 | http://www.w3.org/2000/01/rdf-schema#comment | "Netrins are secreted molecules with roles in axon guidance and angiogenesis. We identified Netrin-4 as a gene specifically overexpressed in VEGF-stimulated endothelial cells (EC) in vitro as well as in vivo. Knockdown of Netrin-4 expression in EC increased their ability to form tubular structures on Matrigel. To identify which receptor is involved, we showed by quantitative RT-PCR that EC express three of the six Netrin-1 cognate receptors: neogenin, Unc5B, and Unc5C. In contrast to Netrin-1, Netrin-4 bound only to neogenin but not to Unc5B or Unc5C receptors. Neutralization of Netrin-4 binding to neogenin by blocking antibodies abolished the chemotactic effect of Netrin-4. Furthermore, the silencing of either neogenin or Unc5B abolished Netrin-4 inhibitory effect on EC migration, suggesting that both receptors are essential for its function in vitro. Coimmunoprecipitation experiments demonstrated that Netrin-4 increased the association between Unc5B and neogenin on VEGF- or FGF-2-stimulated EC. Finally, we showed that Netrin-4 significantly reduced pathological angiogenesis in Matrigel and laser-induced choroidal neovascularization models. Interestingly, Netrin-4, neogenin, and Unc5B receptor expression was up-regulated in choroidal neovessel EC after laser injury. Moreover, Netrin-4 overexpression delayed tumor angiogenesis in a model of s.c. xenograft. We propose that Netrin-4 acts as an antiangiogenic factor through binding to neogenin and recruitment of Unc5B."xsd:string |
| http://purl.uniprot.org/citations/18719102 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0804008105"xsd:string |
| http://purl.uniprot.org/citations/18719102 | http://purl.uniprot.org/core/author | "Plouet J."xsd:string |
| http://purl.uniprot.org/citations/18719102 | http://purl.uniprot.org/core/author | "Feumi C."xsd:string |
| http://purl.uniprot.org/citations/18719102 | http://purl.uniprot.org/core/author | "Lavalette S."xsd:string |
| http://purl.uniprot.org/citations/18719102 | http://purl.uniprot.org/core/author | "Raoul W."xsd:string |
| http://purl.uniprot.org/citations/18719102 | http://purl.uniprot.org/core/author | "Sennlaub F."xsd:string |
| http://purl.uniprot.org/citations/18719102 | http://purl.uniprot.org/core/author | "Merkulova T."xsd:string |
| http://purl.uniprot.org/citations/18719102 | http://purl.uniprot.org/core/author | "Ruchoux M.M."xsd:string |
| http://purl.uniprot.org/citations/18719102 | http://purl.uniprot.org/core/author | "Alemany M."xsd:string |
| http://purl.uniprot.org/citations/18719102 | http://purl.uniprot.org/core/author | "Tobelem G."xsd:string |
| http://purl.uniprot.org/citations/18719102 | http://purl.uniprot.org/core/author | "Ropert S."xsd:string |
| http://purl.uniprot.org/citations/18719102 | http://purl.uniprot.org/core/author | "Leconte L."xsd:string |
| http://purl.uniprot.org/citations/18719102 | http://purl.uniprot.org/core/author | "Poupon M.F."xsd:string |
| http://purl.uniprot.org/citations/18719102 | http://purl.uniprot.org/core/author | "Assayag F."xsd:string |
| http://purl.uniprot.org/citations/18719102 | http://purl.uniprot.org/core/author | "Bouras I."xsd:string |
| http://purl.uniprot.org/citations/18719102 | http://purl.uniprot.org/core/author | "Feron J.G."xsd:string |
| http://purl.uniprot.org/citations/18719102 | http://purl.uniprot.org/core/author | "Jie T.X."xsd:string |
| http://purl.uniprot.org/citations/18719102 | http://purl.uniprot.org/core/author | "Lejmi E."xsd:string |
| http://purl.uniprot.org/citations/18719102 | http://purl.uniprot.org/core/author | "Maitre-Boube M."xsd:string |
| http://purl.uniprot.org/citations/18719102 | http://purl.uniprot.org/core/author | "Pedron-Mazoyer S."xsd:string |
| http://purl.uniprot.org/citations/18719102 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18719102 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/18719102 | http://purl.uniprot.org/core/pages | "12491-12496"xsd:string |