| http://purl.uniprot.org/citations/18719252 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18719252 | http://www.w3.org/2000/01/rdf-schema#comment | "Current yeast interactome network maps contain several hundred molecular complexes with limited and somewhat controversial representation of direct binary interactions. We carried out a comparative quality assessment of current yeast interactome data sets, demonstrating that high-throughput yeast two-hybrid (Y2H) screening provides high-quality binary interaction information. Because a large fraction of the yeast binary interactome remains to be mapped, we developed an empirically controlled mapping framework to produce a "second-generation" high-quality, high-throughput Y2H data set covering approximately 20% of all yeast binary interactions. Both Y2H and affinity purification followed by mass spectrometry (AP/MS) data are of equally high quality but of a fundamentally different and complementary nature, resulting in networks with different topological and biological properties. Compared to co-complex interactome models, this binary map is enriched for transient signaling interactions and intercomplex connections with a highly significant clustering between essential proteins. Rather than correlating with essentiality, protein connectivity correlates with genetic pleiotropy."xsd:string |
| http://purl.uniprot.org/citations/18719252 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1158684"xsd:string |
| http://purl.uniprot.org/citations/18719252 | http://purl.uniprot.org/core/author | "Hudson M.E."xsd:string |
| http://purl.uniprot.org/citations/18719252 | http://purl.uniprot.org/core/author | "Fan C."xsd:string |
| http://purl.uniprot.org/citations/18719252 | http://purl.uniprot.org/core/author | "Li N."xsd:string |
| http://purl.uniprot.org/citations/18719252 | http://purl.uniprot.org/core/author | "Moore T."xsd:string |
| http://purl.uniprot.org/citations/18719252 | http://purl.uniprot.org/core/author | "Park J."xsd:string |
| http://purl.uniprot.org/citations/18719252 | http://purl.uniprot.org/core/author | "Snyder M."xsd:string |
| http://purl.uniprot.org/citations/18719252 | http://purl.uniprot.org/core/author | "Yu H."xsd:string |
| http://purl.uniprot.org/citations/18719252 | http://purl.uniprot.org/core/author | "Xin X."xsd:string |
| http://purl.uniprot.org/citations/18719252 | http://purl.uniprot.org/core/author | "Simon C."xsd:string |
| http://purl.uniprot.org/citations/18719252 | http://purl.uniprot.org/core/author | "Sahalie J."xsd:string |
| http://purl.uniprot.org/citations/18719252 | http://purl.uniprot.org/core/author | "Vidal M."xsd:string |
| http://purl.uniprot.org/citations/18719252 | http://purl.uniprot.org/core/author | "Tam S."xsd:string |
| http://purl.uniprot.org/citations/18719252 | http://purl.uniprot.org/core/author | "Hill D.E."xsd:string |
| http://purl.uniprot.org/citations/18719252 | http://purl.uniprot.org/core/author | "Braun P."xsd:string |
| http://purl.uniprot.org/citations/18719252 | http://purl.uniprot.org/core/author | "Gebreab F."xsd:string |
| http://purl.uniprot.org/citations/18719252 | http://purl.uniprot.org/core/author | "Hao T."xsd:string |
| http://purl.uniprot.org/citations/18719252 | http://purl.uniprot.org/core/author | "Roth F.P."xsd:string |
| http://purl.uniprot.org/citations/18719252 | http://purl.uniprot.org/core/author | "Boone C."xsd:string |
| http://purl.uniprot.org/citations/18719252 | http://purl.uniprot.org/core/author | "Cusick M.E."xsd:string |
| http://purl.uniprot.org/citations/18719252 | http://purl.uniprot.org/core/author | "Hirozane-Kishikawa T."xsd:string |
| http://purl.uniprot.org/citations/18719252 | http://purl.uniprot.org/core/author | "Vazquez A."xsd:string |
| http://purl.uniprot.org/citations/18719252 | http://purl.uniprot.org/core/author | "Lemmens I."xsd:string |