http://purl.uniprot.org/citations/18723004 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/18723004 | http://www.w3.org/2000/01/rdf-schema#comment | "Neonatal brain iron deficiency occurs after insufficient maternal dietary iron intake, maternal hypertension, and maternal diabetes mellitus and results in short and long-term neurologic and behavioral deficits. Early iron deficiency affects the genomic profile of the developing hippocampus that persists despite iron repletion. The purpose of the present study was threefold: 1) quantitative PCR confirmation of our previous microarray results, demonstrating upregulation of a network of genes leading to beta-amyloid production and implicated in Alzheimer disease etiology in iron-deficient anemic rat pups at the time of hippocampal differentiation; 2) investigation of the potential contributions of iron deficiency anemia and iron treatment to this differential gene expression in the hippocampus; and 3) investigation of these genes over a developmental time course in a mouse model where iron deficiency is limited to hippocampus, is not accompanied by anemia and is not repletable. Quantitative PCR confirmed altered regulation in 6 of 7 Alzheimer-related genes (Apbb1, C1qa, Clu, App, Cst3, Fn1, Htatip) in iron-deficient rats relative to iron-sufficient controls at P15. Comparison of untreated to treated iron-deficient animals at this age suggested the strong role of iron deficiency, not treatment, in the upregulation of this gene network. The non-anemic hippocampal iron-deficient mouse demonstrated upregulation of all 7 genes in this pathway from P5 to P25. Our results suggest a role for neonatal iron deficiency in dysregulation of genes that may set the stage for long-term neurodegenerative disease and that this may occur through a histone modification mechanism."xsd:string |
http://purl.uniprot.org/citations/18723004 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.brainres.2008.07.109"xsd:string |
http://purl.uniprot.org/citations/18723004 | http://purl.uniprot.org/core/author | "Petryk A."xsd:string |
http://purl.uniprot.org/citations/18723004 | http://purl.uniprot.org/core/author | "Georgieff M.K."xsd:string |
http://purl.uniprot.org/citations/18723004 | http://purl.uniprot.org/core/author | "Magid R."xsd:string |
http://purl.uniprot.org/citations/18723004 | http://purl.uniprot.org/core/author | "Carlson E.S."xsd:string |
http://purl.uniprot.org/citations/18723004 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
http://purl.uniprot.org/citations/18723004 | http://purl.uniprot.org/core/name | "Brain Res"xsd:string |
http://purl.uniprot.org/citations/18723004 | http://purl.uniprot.org/core/pages | "75-83"xsd:string |
http://purl.uniprot.org/citations/18723004 | http://purl.uniprot.org/core/title | "Iron deficiency alters expression of genes implicated in Alzheimer disease pathogenesis."xsd:string |
http://purl.uniprot.org/citations/18723004 | http://purl.uniprot.org/core/volume | "1237"xsd:string |
http://purl.uniprot.org/citations/18723004 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18723004 |
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