| http://purl.uniprot.org/citations/18723082 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18723082 | http://www.w3.org/2000/01/rdf-schema#comment | "Recent studies suggest that the formyl-peptide-receptor-like-1 (FPRL1) plays an essential role in the inflammatory responses of host defense mechanisms and neurodegenerative disorders such as Alzheimer's disease (AD). We therefore analyzed whether amyloid beta1-42 (Abeta1-42) increased the activity of phospholipase D (PLD) via FPRL1, which is an enzyme involved in the secretion, endocytosis and receptor signaling. PLD activity was determined using a transphosphatidylation assay. The internalization of Abeta1-42 via FPRL1 was visualized using fluorescence microscopy and quantified by ELISA (Enzyme Linked Immunosorbent Assay). Determining receptor activity by extracellular-signal regulated kinases 1/2 (ERK1/2) phosphorylation and cAMP level measurement verified the Abeta1-42-induced activation of FPRL1. We were able to show that Abeta1-42 is rapidly internalized via FPRL1 in astrocytes and microglia. PLD was additionally activated by Abeta1-42 and via FPRL1 in rat glial cells. Furthermore, the ERK1/2 phosphorylation by FPRL1 agonists was dependent on the PLD product phosphatidic acid (PA). Together, these data suggest that PLD plays an important role in the regulation of Abeta1-42-induced endocytosis and FPRL1 receptor signaling."xsd:string |
| http://purl.uniprot.org/citations/18723082 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuroscience.2008.07.042"xsd:string |
| http://purl.uniprot.org/citations/18723082 | http://purl.uniprot.org/core/author | "Koch T."xsd:string |
| http://purl.uniprot.org/citations/18723082 | http://purl.uniprot.org/core/author | "Konrad M."xsd:string |
| http://purl.uniprot.org/citations/18723082 | http://purl.uniprot.org/core/author | "Lucius R."xsd:string |
| http://purl.uniprot.org/citations/18723082 | http://purl.uniprot.org/core/author | "Pufe T."xsd:string |
| http://purl.uniprot.org/citations/18723082 | http://purl.uniprot.org/core/author | "Brandenburg L.O."xsd:string |
| http://purl.uniprot.org/citations/18723082 | http://purl.uniprot.org/core/author | "Wruck C."xsd:string |
| http://purl.uniprot.org/citations/18723082 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18723082 | http://purl.uniprot.org/core/name | "Neuroscience"xsd:string |
| http://purl.uniprot.org/citations/18723082 | http://purl.uniprot.org/core/pages | "266-276"xsd:string |
| http://purl.uniprot.org/citations/18723082 | http://purl.uniprot.org/core/title | "Involvement of formyl-peptide-receptor-like-1 and phospholipase D in the internalization and signal transduction of amyloid beta 1-42 in glial cells."xsd:string |
| http://purl.uniprot.org/citations/18723082 | http://purl.uniprot.org/core/volume | "156"xsd:string |
| http://purl.uniprot.org/citations/18723082 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18723082 |
| http://purl.uniprot.org/citations/18723082 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18723082 |
| http://purl.uniprot.org/uniprot/P05067#attribution-23E2B983BA4F812F4570C150E9B63E6C | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18723082 |