| http://purl.uniprot.org/citations/18728397 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18728397 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18728397 | http://www.w3.org/2000/01/rdf-schema#comment | "Accurate chromosome segregation relies on the mitotic spindle checkpoint. This checkpoint acts to restrict ubiquitin ligase activity of the Anaphase-promoting complex (APC/C) in mitosis until all chromosomes are bipolarly attached to the mitotic spindle. We performed a functional RNAi-based screen to identify De-ubiquitinating enzymes (Dubs) involved in mitotic progression. We identified Usp39 as a new factor required to maintain the spindle checkpoint and support successful cytokinesis. Strikingly, although Usp39 clearly contains an ubiquitin-protease domain, we show that Usp39 is entirely deprived of Dub activity. However, consistent wilt a previously described role for Usp39 in mRNA processing, we observed specific reduction in Aurora B-mRNA levels after depletion of Usp39. Although we find that exogenously expressed Aurora B cDNA is not sufficient to rescue the checkpoint defect of Usp39-depleted cells, Aurora B expression is restored. Our observations suggest Usp39 to be involved in splicing of Aurora B and other mRNAs that are essential for proper spindle checkpoint function."xsd:string |
| http://purl.uniprot.org/citations/18728397 | http://purl.org/dc/terms/identifier | "doi:10.4161/cc.7.17.6553"xsd:string |
| http://purl.uniprot.org/citations/18728397 | http://purl.org/dc/terms/identifier | "doi:10.4161/cc.7.17.6553"xsd:string |
| http://purl.uniprot.org/citations/18728397 | http://purl.uniprot.org/core/author | "Sixma T.K."xsd:string |
| http://purl.uniprot.org/citations/18728397 | http://purl.uniprot.org/core/author | "Sixma T.K."xsd:string |
| http://purl.uniprot.org/citations/18728397 | http://purl.uniprot.org/core/author | "Medema R.H."xsd:string |
| http://purl.uniprot.org/citations/18728397 | http://purl.uniprot.org/core/author | "Medema R.H."xsd:string |
| http://purl.uniprot.org/citations/18728397 | http://purl.uniprot.org/core/author | "Wolthuis R.M."xsd:string |
| http://purl.uniprot.org/citations/18728397 | http://purl.uniprot.org/core/author | "Wolthuis R.M."xsd:string |
| http://purl.uniprot.org/citations/18728397 | http://purl.uniprot.org/core/author | "Luna-Vargas M.P."xsd:string |
| http://purl.uniprot.org/citations/18728397 | http://purl.uniprot.org/core/author | "Luna-Vargas M.P."xsd:string |
| http://purl.uniprot.org/citations/18728397 | http://purl.uniprot.org/core/author | "van Leuken R.J."xsd:string |
| http://purl.uniprot.org/citations/18728397 | http://purl.uniprot.org/core/author | "van Leuken R.J."xsd:string |
| http://purl.uniprot.org/citations/18728397 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18728397 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18728397 | http://purl.uniprot.org/core/name | "Cell Cycle"xsd:string |
| http://purl.uniprot.org/citations/18728397 | http://purl.uniprot.org/core/name | "Cell Cycle"xsd:string |
| http://purl.uniprot.org/citations/18728397 | http://purl.uniprot.org/core/pages | "2710-2719"xsd:string |
| http://purl.uniprot.org/citations/18728397 | http://purl.uniprot.org/core/pages | "2710-2719"xsd:string |
| http://purl.uniprot.org/citations/18728397 | http://purl.uniprot.org/core/title | "Usp39 is essential for mitotic spindle checkpoint integrity and controls mRNA-levels of aurora B."xsd:string |
| http://purl.uniprot.org/citations/18728397 | http://purl.uniprot.org/core/title | "Usp39 is essential for mitotic spindle checkpoint integrity and controls mRNA-levels of aurora B."xsd:string |
| http://purl.uniprot.org/citations/18728397 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/18728397 | http://purl.uniprot.org/core/volume | "7"xsd:string |