| http://purl.uniprot.org/citations/18752070 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18752070 | http://www.w3.org/2000/01/rdf-schema#comment | "Leptin is a key mediator in the maintenance of neuroendocrine homeostasis. The aim of this study was to determine the changes in serum leptin, tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), nitric oxide (NO) levels in patients with hyperprolactinemia. The study consists of 16 consecutive patients with high prolactin (PRL) levels (group I) and a control group of 11 normoprolactinemic patients (group II). Pituitary tumor tissues of patients in groups I and II were analyzed for immunohistochemical (IHC) expression of prolactin and leptin. Group I has significantly higher levels of leptin than group II (P < 0.001). There is a strong correlation between PRL and leptin concentrations in group I. However, there were no statistically significant differences for NO, TNF-alpha, IL-6 between the two groups. IHC staining showed that there was strong immunoreactivity for leptin protein in PRL-secreting pituitary adenomas. Double immunostaining of adenoma tissues with PRL and leptin showed that the adenoma cells expressed both. These findings together are suggestive that leptin co-secretion from a prolactinoma may be the cause of increased serum leptin concentration, independently from the peripheral action of prolactin."xsd:string |
| http://purl.uniprot.org/citations/18752070 | http://purl.org/dc/terms/identifier | "doi:10.1007/s11102-008-0140-4"xsd:string |
| http://purl.uniprot.org/citations/18752070 | http://purl.uniprot.org/core/author | "Balci H."xsd:string |
| http://purl.uniprot.org/citations/18752070 | http://purl.uniprot.org/core/author | "Bolayirli M."xsd:string |
| http://purl.uniprot.org/citations/18752070 | http://purl.uniprot.org/core/author | "Oz B."xsd:string |
| http://purl.uniprot.org/citations/18752070 | http://purl.uniprot.org/core/author | "Kapucu A."xsd:string |
| http://purl.uniprot.org/citations/18752070 | http://purl.uniprot.org/core/author | "Akgun-Dar K."xsd:string |
| http://purl.uniprot.org/citations/18752070 | http://purl.uniprot.org/core/author | "Gazioglu N."xsd:string |
| http://purl.uniprot.org/citations/18752070 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/18752070 | http://purl.uniprot.org/core/name | "Pituitary"xsd:string |
| http://purl.uniprot.org/citations/18752070 | http://purl.uniprot.org/core/pages | "170-176"xsd:string |
| http://purl.uniprot.org/citations/18752070 | http://purl.uniprot.org/core/title | "The relationship between prolactin (PRL), leptin, nitric oxide (NO), and cytokines in patients with hyperprolactinemia."xsd:string |
| http://purl.uniprot.org/citations/18752070 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/18752070 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18752070 |
| http://purl.uniprot.org/citations/18752070 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18752070 |
| http://purl.uniprot.org/uniprot/#_A6XMH3-mappedCitation-18752070 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18752070 |
| http://purl.uniprot.org/uniprot/#_Q5THQ0-mappedCitation-18752070 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18752070 |
| http://purl.uniprot.org/uniprot/#_P01236-mappedCitation-18752070 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18752070 |
| http://purl.uniprot.org/uniprot/#_Q5I0G2-mappedCitation-18752070 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18752070 |
| http://purl.uniprot.org/uniprot/#_Q9UQW0-mappedCitation-18752070 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18752070 |
| http://purl.uniprot.org/uniprot/#_V9H0U8-mappedCitation-18752070 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18752070 |
| http://purl.uniprot.org/uniprot/V9H0U8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18752070 |
| http://purl.uniprot.org/uniprot/P01236 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18752070 |
| http://purl.uniprot.org/uniprot/Q5THQ0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18752070 |