| http://purl.uniprot.org/citations/18761086 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18761086 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18761086 | http://www.w3.org/2000/01/rdf-schema#comment | "The transcription factor NF-kappaB is transiently activated by a wide variety of stress signals, including pro-inflammatory mediators, and regulates the expression of genes with e.g., immune, inflammatory, and anti-apoptotic functions. The strength and kinetics of its induction, as well as its ultimate down-regulation is subject to multiple levels of regulation. One such regulatory protein is X chromosome-linked inhibitor of apoptosis (XIAP) that, besides its anti-apoptotic properties, has been shown to enhance NF-kappaB activity, however, the underlying molecular mechanism has remained elusive. We show here that following TNFalpha stimulation XIAP regulates a second wave of NF-kappaB activation. XIAP interacts with and ubiquitinates MEKK2, a kinase that has previously been associated with bi-phasic NF-kappaB activation. We conclude that, through interaction with MEKK2, XIAP functions in an ubiquitin ligase dependent manner to evoke a second wave of NF-kappaB activation, resulting in the modulation of NF-kappaB target gene expression."xsd:string |
| http://purl.uniprot.org/citations/18761086 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cellsig.2008.08.004"xsd:string |
| http://purl.uniprot.org/citations/18761086 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cellsig.2008.08.004"xsd:string |
| http://purl.uniprot.org/citations/18761086 | http://purl.uniprot.org/core/author | "de Martin R."xsd:string |
| http://purl.uniprot.org/citations/18761086 | http://purl.uniprot.org/core/author | "de Martin R."xsd:string |
| http://purl.uniprot.org/citations/18761086 | http://purl.uniprot.org/core/author | "Hofer-Warbinek R."xsd:string |
| http://purl.uniprot.org/citations/18761086 | http://purl.uniprot.org/core/author | "Hofer-Warbinek R."xsd:string |
| http://purl.uniprot.org/citations/18761086 | http://purl.uniprot.org/core/author | "Winsauer G."xsd:string |
| http://purl.uniprot.org/citations/18761086 | http://purl.uniprot.org/core/author | "Winsauer G."xsd:string |
| http://purl.uniprot.org/citations/18761086 | http://purl.uniprot.org/core/author | "Resch U."xsd:string |
| http://purl.uniprot.org/citations/18761086 | http://purl.uniprot.org/core/author | "Resch U."xsd:string |
| http://purl.uniprot.org/citations/18761086 | http://purl.uniprot.org/core/author | "Schichl Y.M."xsd:string |
| http://purl.uniprot.org/citations/18761086 | http://purl.uniprot.org/core/author | "Schichl Y.M."xsd:string |
| http://purl.uniprot.org/citations/18761086 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18761086 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18761086 | http://purl.uniprot.org/core/name | "Cell. Signal."xsd:string |
| http://purl.uniprot.org/citations/18761086 | http://purl.uniprot.org/core/name | "Cell. Signal."xsd:string |
| http://purl.uniprot.org/citations/18761086 | http://purl.uniprot.org/core/pages | "2107-2112"xsd:string |
| http://purl.uniprot.org/citations/18761086 | http://purl.uniprot.org/core/pages | "2107-2112"xsd:string |
| http://purl.uniprot.org/citations/18761086 | http://purl.uniprot.org/core/title | "XIAP regulates bi-phasic NF-kappaB induction involving physical interaction and ubiquitination of MEKK2."xsd:string |
| http://purl.uniprot.org/citations/18761086 | http://purl.uniprot.org/core/title | "XIAP regulates bi-phasic NF-kappaB induction involving physical interaction and ubiquitination of MEKK2."xsd:string |
| http://purl.uniprot.org/citations/18761086 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/18761086 | http://purl.uniprot.org/core/volume | "20"xsd:string |