| http://purl.uniprot.org/citations/18761323 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18761323 | http://www.w3.org/2000/01/rdf-schema#comment | "Caspases are a family of aspartate-specific cysteine proteases that have been well characterized for their function in apoptosis signaling. Caspase-8 is implicated as an initiator caspase in death receptor-induced signaling to apoptosis and has been studied most extensively for its role in CD95-induced cell death. CD95 stimulation induces the binding of caspase-8 to a death-inducing signaling complex, leading to its autocatalytic cleavage and the formation of a caspase-8 homodimer, which is subsequently released into the cytosol where it further mediates the apoptotic signaling cascade. Over the past few years, however, several non-apoptotic functions for caspase-8 have been described, indicating that this protease plays a much more diverse role than previously assumed. Here we review the role of caspase-8 in embryonic development, monocyte differentiation, T and B cell proliferation, and the activation of NF-kappaB."xsd:string |
| http://purl.uniprot.org/citations/18761323 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bcp.2008.07.034"xsd:string |
| http://purl.uniprot.org/citations/18761323 | http://purl.uniprot.org/core/author | "Beyaert R."xsd:string |
| http://purl.uniprot.org/citations/18761323 | http://purl.uniprot.org/core/author | "Maelfait J."xsd:string |
| http://purl.uniprot.org/citations/18761323 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18761323 | http://purl.uniprot.org/core/name | "Biochem Pharmacol"xsd:string |
| http://purl.uniprot.org/citations/18761323 | http://purl.uniprot.org/core/pages | "1365-1373"xsd:string |
| http://purl.uniprot.org/citations/18761323 | http://purl.uniprot.org/core/title | "Non-apoptotic functions of caspase-8."xsd:string |
| http://purl.uniprot.org/citations/18761323 | http://purl.uniprot.org/core/volume | "76"xsd:string |
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