| http://purl.uniprot.org/citations/18761620 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18761620 | http://www.w3.org/2000/01/rdf-schema#comment | "Bacterial protein secretion is catalysed by the SecYEG protein-conducting channel complexed with the SecA ATPase motor. To gain insight into the SecA-SecYEG interaction we used peptide arrays, thermodynamic quantification, mutagenesis and functional assays. Our data reveal that: (i) SecA binds with low affinity on several, peripheral, exposed SecYEG sites. This largely electrostatic association is modulated by temperature and nucleotides. (ii) Binding sites cluster in five major binding 'regions': three that are exclusively cytoplasmic and two that reach the periplasm. (iii) Both the N-terminal and c-terminal regions of SecA participate in binding interactions and share some sites. (iv) Several of these sites are essential for translocase catalysis. Our data provide residue-level dissection of the SecYEG-SecA interaction. Two models of assembly of SecA on dimeric SecYEG are discussed."xsd:string |
| http://purl.uniprot.org/citations/18761620 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1365-2958.2008.06402.x"xsd:string |
| http://purl.uniprot.org/citations/18761620 | http://purl.uniprot.org/core/author | "Economou A."xsd:string |
| http://purl.uniprot.org/citations/18761620 | http://purl.uniprot.org/core/author | "Kalodimos C.G."xsd:string |
| http://purl.uniprot.org/citations/18761620 | http://purl.uniprot.org/core/author | "Karamanou S."xsd:string |
| http://purl.uniprot.org/citations/18761620 | http://purl.uniprot.org/core/author | "Papanikou E."xsd:string |
| http://purl.uniprot.org/citations/18761620 | http://purl.uniprot.org/core/author | "Bariami V."xsd:string |
| http://purl.uniprot.org/citations/18761620 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18761620 | http://purl.uniprot.org/core/name | "Mol Microbiol"xsd:string |
| http://purl.uniprot.org/citations/18761620 | http://purl.uniprot.org/core/pages | "311-322"xsd:string |
| http://purl.uniprot.org/citations/18761620 | http://purl.uniprot.org/core/title | "Assembly of the translocase motor onto the preprotein-conducting channel."xsd:string |
| http://purl.uniprot.org/citations/18761620 | http://purl.uniprot.org/core/volume | "70"xsd:string |
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