| http://purl.uniprot.org/citations/18762249 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18762249 | http://www.w3.org/2000/01/rdf-schema#comment | "Mutations in the receptor tyrosine kinase Ror2 account for Brachydactyly type B and Robinow Syndrome. We have identified two novel factors interacting with the Ror2 intracellular domain. TAK1 (TGF-beta activated kinase 1), a MAP3K, interacts with Ror2 and phosphorylates its intracellular carboxyterminal serine/thronine/proline-rich (STP) domain. This TAK1-dependent phosphorylation of Ror2 induces phosphorylation of tyrosine-residues including a MAPK-like TGY-motif. The TAK1-dependent phosphorylation is enhanced by a second cytosolic factor, PRTB, which interacts with Ror2 and with TAK1 as well. The TAK1-dependent Tyr-phosphorylation of Ror2 is not mediated by the Ror2 tyrosine kinase domain and seems predominantly triggered by cytosolic kinases. Wnt-ligand binding differentially controls the Ror2/TAK1 interaction. Wnt1-binding displaces TAK1 from Ror2 while Wnt3a and Wnt5a are unable to do so thus modifying TAK1's capacity to cause phosphorylation of Ror2. Ror2 seems to act as a Wnt co-receptor enhancing Wnt-dependent canonical pathways while Tyr- and Ser/Thr-phosphorylation of Ror2 negatively controls the efficiency of these pathways. We propose that the level of the Wnt-ligand-regulated phosphorylation by cytosolic factors determines whether Ror2 acts as a stimulator or as an inhibitor of canonical Wnt-signalling."xsd:string |
| http://purl.uniprot.org/citations/18762249 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cellsig.2008.08.009"xsd:string |
| http://purl.uniprot.org/citations/18762249 | http://purl.uniprot.org/core/author | "Mundlos S."xsd:string |
| http://purl.uniprot.org/citations/18762249 | http://purl.uniprot.org/core/author | "Stricker S."xsd:string |
| http://purl.uniprot.org/citations/18762249 | http://purl.uniprot.org/core/author | "Hoffmann A."xsd:string |
| http://purl.uniprot.org/citations/18762249 | http://purl.uniprot.org/core/author | "Tylzanowski P."xsd:string |
| http://purl.uniprot.org/citations/18762249 | http://purl.uniprot.org/core/author | "Gross G."xsd:string |
| http://purl.uniprot.org/citations/18762249 | http://purl.uniprot.org/core/author | "Winkel A."xsd:string |
| http://purl.uniprot.org/citations/18762249 | http://purl.uniprot.org/core/author | "Seiffart V."xsd:string |
| http://purl.uniprot.org/citations/18762249 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18762249 | http://purl.uniprot.org/core/name | "Cell Signal"xsd:string |
| http://purl.uniprot.org/citations/18762249 | http://purl.uniprot.org/core/pages | "2134-2144"xsd:string |
| http://purl.uniprot.org/citations/18762249 | http://purl.uniprot.org/core/title | "Wnt-ligand-dependent interaction of TAK1 (TGF-beta-activated kinase-1) with the receptor tyrosine kinase Ror2 modulates canonical Wnt-signalling."xsd:string |
| http://purl.uniprot.org/citations/18762249 | http://purl.uniprot.org/core/volume | "20"xsd:string |
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| http://purl.uniprot.org/citations/18762249 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18762249 |
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