| http://purl.uniprot.org/citations/18762566 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18762566 | http://www.w3.org/2000/01/rdf-schema#comment | "Primary neonatal T cell responses comprise both T helper (Th) cell subsets, but Th1 cells express high levels of interleukin 13 receptor alpha1 (IL-13R alpha 1), which heterodimerizes with IL-4R alpha. During secondary antigen challenge, Th2-produced IL-4 triggers the apoptosis of Th1 cells via IL-4R alpha/IL-13R alpha 1, thus explaining the Th2 bias in neonates. We show that neonates acquire the ability to overcome the Th2 bias and generate Th1 responses starting 6 d after birth. This transition was caused by the developmental maturation of CD8 alpha(+)CD4(-) dendritic cells (DCs), which were minimal in number during the first few days of birth and produced low levels of IL-12. This lack of IL-12 sustained the expression of IL-13R alpha 1 on Th1 cells. By day 6 after birth, however, a significant number of CD8 alpha(+)CD4(-) DCs accumulated in the spleen and produced IL-12, which triggered the down-regulation of IL-13R alpha 1 expression on Th1 cells, thus protecting them against IL-4-driven apoptosis."xsd:string |
| http://purl.uniprot.org/citations/18762566 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20071371"xsd:string |
| http://purl.uniprot.org/citations/18762566 | http://purl.uniprot.org/core/author | "Lee H.H."xsd:string |
| http://purl.uniprot.org/citations/18762566 | http://purl.uniprot.org/core/author | "Jain R."xsd:string |
| http://purl.uniprot.org/citations/18762566 | http://purl.uniprot.org/core/author | "Ellis J.S."xsd:string |
| http://purl.uniprot.org/citations/18762566 | http://purl.uniprot.org/core/author | "Zaghouani H."xsd:string |
| http://purl.uniprot.org/citations/18762566 | http://purl.uniprot.org/core/author | "Divekar R."xsd:string |
| http://purl.uniprot.org/citations/18762566 | http://purl.uniprot.org/core/author | "Guloglu F.B."xsd:string |
| http://purl.uniprot.org/citations/18762566 | http://purl.uniprot.org/core/author | "Hoeman C.M."xsd:string |
| http://purl.uniprot.org/citations/18762566 | http://purl.uniprot.org/core/author | "Tartar D.M."xsd:string |
| http://purl.uniprot.org/citations/18762566 | http://purl.uniprot.org/core/author | "Hardaway J.C."xsd:string |
| http://purl.uniprot.org/citations/18762566 | http://purl.uniprot.org/core/author | "Haymaker C.L."xsd:string |
| http://purl.uniprot.org/citations/18762566 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18762566 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/18762566 | http://purl.uniprot.org/core/pages | "2269-2280"xsd:string |
| http://purl.uniprot.org/citations/18762566 | http://purl.uniprot.org/core/title | "Delayed maturation of an IL-12-producing dendritic cell subset explains the early Th2 bias in neonatal immunity."xsd:string |
| http://purl.uniprot.org/citations/18762566 | http://purl.uniprot.org/core/volume | "205"xsd:string |
| http://purl.uniprot.org/citations/18762566 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18762566 |
| http://purl.uniprot.org/citations/18762566 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18762566 |
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| http://purl.uniprot.org/uniprot/#_Q3ZAX5-mappedCitation-18762566 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18762566 |
| http://purl.uniprot.org/uniprot/#_P43431-mappedCitation-18762566 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18762566 |
| http://purl.uniprot.org/uniprot/#_P43432-mappedCitation-18762566 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18762566 |
| http://purl.uniprot.org/uniprot/#_Q549G3-mappedCitation-18762566 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18762566 |