| http://purl.uniprot.org/citations/18762715 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18762715 | http://www.w3.org/2000/01/rdf-schema#comment | "The mechanism of glycerol transport by human aquaporin 9 (hAQP9), which is a liver-specific AQP water channel and can also transport glycerol, was investigated by using the Xenopus laevis oocyte expression system. It was found that specific glycerol uptake by hAQP9 was concentration-dependent (saturable) at 25 degrees C, conforming to the Michaelis-Menten kinetics with the maximum transport rate (J(max)) of 0.84 pmol/min/oocyte and the Michaelis constant (K(m)) of 9.2 microM, and temperature-dependent, being reduced by about 70% when temperature was lowered from 25 degrees C to 4 degrees C. Such dependences on concentration and temperature are characteristic of a carrier-mediated type of mechanism rather than a channel type, which is expected not to depend on them. Furthermore, several glycerol-related compounds, such as monoacetin, were found to specifically inhibit hAQP9-mediated glycerol uptake, indicating a possibility of competition with glycerol. hAQP9-mediated glycerol uptake was, however, found not to require Na+. All these results suggest that hAQP9 functions as a facilitative carrier for glycerol, although it had been believed to function as a channel. Findings in the present study provide novel insight into its glycerol-transporting mechanism and would help exploring a possibility that hAQP9 inhibitors might help lower blood glucose level by reducing gluconeogenesis by limiting hepatic glycerol uptake."xsd:string |
| http://purl.uniprot.org/citations/18762715 | http://purl.org/dc/terms/identifier | "doi:10.2133/dmpk.23.279"xsd:string |
| http://purl.uniprot.org/citations/18762715 | http://purl.uniprot.org/core/author | "Inoue K."xsd:string |
| http://purl.uniprot.org/citations/18762715 | http://purl.uniprot.org/core/author | "Watanabe J."xsd:string |
| http://purl.uniprot.org/citations/18762715 | http://purl.uniprot.org/core/author | "Ishii M."xsd:string |
| http://purl.uniprot.org/citations/18762715 | http://purl.uniprot.org/core/author | "Yuasa H."xsd:string |
| http://purl.uniprot.org/citations/18762715 | http://purl.uniprot.org/core/author | "Katano T."xsd:string |
| http://purl.uniprot.org/citations/18762715 | http://purl.uniprot.org/core/author | "Urano K."xsd:string |
| http://purl.uniprot.org/citations/18762715 | http://purl.uniprot.org/core/author | "Ohta K.Y."xsd:string |
| http://purl.uniprot.org/citations/18762715 | http://purl.uniprot.org/core/author | "Ohgusu Y."xsd:string |
| http://purl.uniprot.org/citations/18762715 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18762715 | http://purl.uniprot.org/core/name | "Drug Metab Pharmacokinet"xsd:string |
| http://purl.uniprot.org/citations/18762715 | http://purl.uniprot.org/core/pages | "279-284"xsd:string |
| http://purl.uniprot.org/citations/18762715 | http://purl.uniprot.org/core/title | "Functional characterization of human aquaporin 9 as a facilitative glycerol carrier."xsd:string |
| http://purl.uniprot.org/citations/18762715 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/18762715 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18762715 |
| http://purl.uniprot.org/citations/18762715 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18762715 |
| http://purl.uniprot.org/uniprot/#_B4DT52-mappedCitation-18762715 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18762715 |
| http://purl.uniprot.org/uniprot/#_H0YK62-mappedCitation-18762715 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18762715 |
| http://purl.uniprot.org/uniprot/#_P30301-mappedCitation-18762715 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18762715 |
| http://purl.uniprot.org/uniprot/#_P41181-mappedCitation-18762715 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18762715 |
| http://purl.uniprot.org/uniprot/#_O43315-mappedCitation-18762715 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18762715 |
| http://purl.uniprot.org/uniprot/#_P55064-mappedCitation-18762715 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18762715 |
| http://purl.uniprot.org/uniprot/#_P55087-mappedCitation-18762715 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18762715 |