| http://purl.uniprot.org/citations/18769921 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18769921 | http://www.w3.org/2000/01/rdf-schema#comment | "DNA double-strand break (DSB) repair mediated by the Rad51 pathway of homologous recombination is conserved in eukaryotes. In yeast, Rad51 paralogs, Saccharomyces cerevisiae Rad55-Rad57 and Schizosaccharomyces pombe Rhp55-Rhp57, are mediators of Rad51 nucleoprotein formation. The recently discovered S. pombe Sfr1/Dds20 protein has been shown to interact with Rad51 and to operate in the Rad51-dependent DSB repair pathway in parallel to the paralog-mediated pathway. Here we show that Sfr1 is a nuclear protein and acts downstream of Rad50 in DSB processing. sfr1Delta is epistatic to rad18 (-) and rad60 (-), and Sfr1 is a high-copy suppressor of the replication and repair defects of a rad60 mutant. Sfr1 functions in a Cds1-independent UV damage tolerance mechanism. In contrast to mitotic recombination, meiotic recombination is significantly reduced in sfr1Delta strains. Our data indicate that Sfr1 acts in DSB repair mainly outside of S-phase, and is required for wild-type levels of meiotic recombination. We suggest that Sfr1 acts early in recombination and has a specific role in Rad51 filament assembly, distinct from that of the Rad51 paralogs."xsd:string |
| http://purl.uniprot.org/citations/18769921 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00294-008-0212-z"xsd:string |
| http://purl.uniprot.org/citations/18769921 | http://purl.uniprot.org/core/author | "Khasanov F.K."xsd:string |
| http://purl.uniprot.org/citations/18769921 | http://purl.uniprot.org/core/author | "Bashkirov V.I."xsd:string |
| http://purl.uniprot.org/citations/18769921 | http://purl.uniprot.org/core/author | "Kohli J."xsd:string |
| http://purl.uniprot.org/citations/18769921 | http://purl.uniprot.org/core/author | "Korolev V.G."xsd:string |
| http://purl.uniprot.org/citations/18769921 | http://purl.uniprot.org/core/author | "Chepurnaja O.V."xsd:string |
| http://purl.uniprot.org/citations/18769921 | http://purl.uniprot.org/core/author | "Grishchuk A.L."xsd:string |
| http://purl.uniprot.org/citations/18769921 | http://purl.uniprot.org/core/author | "Salakhova A.F."xsd:string |
| http://purl.uniprot.org/citations/18769921 | http://purl.uniprot.org/core/author | "Khasanova O.S."xsd:string |
| http://purl.uniprot.org/citations/18769921 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18769921 | http://purl.uniprot.org/core/name | "Curr Genet"xsd:string |
| http://purl.uniprot.org/citations/18769921 | http://purl.uniprot.org/core/pages | "197-211"xsd:string |
| http://purl.uniprot.org/citations/18769921 | http://purl.uniprot.org/core/title | "Genetic analysis reveals different roles of Schizosaccharomyces pombe sfr1/dds20 in meiotic and mitotic DNA recombination and repair."xsd:string |
| http://purl.uniprot.org/citations/18769921 | http://purl.uniprot.org/core/volume | "54"xsd:string |
| http://purl.uniprot.org/citations/18769921 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18769921 |
| http://purl.uniprot.org/citations/18769921 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18769921 |
| http://purl.uniprot.org/uniprot/Q9USV1#attribution-20E80F1C5ABD2A5F921EE0763AB91BAE | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18769921 |
| http://purl.uniprot.org/uniprot/Q9USV1#attribution-7EFAB49B353015087670F0A6E8FC4A43 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18769921 |
| http://purl.uniprot.org/uniprot/Q9USV1#attribution-CD213F6D92A69903819A234F58709A1F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18769921 |
| http://purl.uniprot.org/uniprot/#_P41410-mappedCitation-18769921 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18769921 |
| http://purl.uniprot.org/uniprot/#_Q10213-mappedCitation-18769921 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18769921 |
| http://purl.uniprot.org/uniprot/#_Q10988-mappedCitation-18769921 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18769921 |
| http://purl.uniprot.org/uniprot/#_P28706-mappedCitation-18769921 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18769921 |