| http://purl.uniprot.org/citations/18771702 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18771702 | http://www.w3.org/2000/01/rdf-schema#comment | "Glycine-extended gastrin (G-Gly) is a mitogen for several gastrointestinal tissues although the mechanisms responsible are ill-defined and it is unknown if G-Gly can influence signalling in Barrett's oesophagus. G-Gly stimulated proliferation in OE19 and OE33 cells in a dose-dependant manner. This was unaffected by a CCK2 receptor antagonist but abolished by COX-2 inhibitors. G-Gly induced proliferation, COX-2 mRNA abundance, and PGE2 secretion, were all abolished by inhibition of JAK2, PI3-kinase, Akt or NF-kappaB. G-Gly stimulated phosphorylation of JAK2 and increased PI3-kinase activity in JAK2 immunoprecipitates. G-Gly increased Akt phosphorylation and kinase activity and NF-kappaB reporter activity in a JAK2-, PI3-kinase- and Akt-sensitive manner. G-Gly increased COX-2 promoter transcription in an Akt and NF-kappaB-dependent manner and also reduced COX-2 mRNA degradation in an Akt-insensitive manner. We conclude that G-Gly induced signalling involves a JAK2/PI3-kinase/Akt/NF-kappaB sequence leading to COX-2 transcription. G-Gly also seems to stabilise COX-2 mRNA via a separate pathway."xsd:string |
| http://purl.uniprot.org/citations/18771702 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.mce.2008.08.004"xsd:string |
| http://purl.uniprot.org/citations/18771702 | http://purl.uniprot.org/core/author | "Beales I.L."xsd:string |
| http://purl.uniprot.org/citations/18771702 | http://purl.uniprot.org/core/author | "Ogunwobi O.O."xsd:string |
| http://purl.uniprot.org/citations/18771702 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18771702 | http://purl.uniprot.org/core/name | "Mol Cell Endocrinol"xsd:string |
| http://purl.uniprot.org/citations/18771702 | http://purl.uniprot.org/core/pages | "94-102"xsd:string |
| http://purl.uniprot.org/citations/18771702 | http://purl.uniprot.org/core/title | "Glycine-extended gastrin stimulates proliferation via JAK2- and Akt-dependent NF-kappaB activation in Barrett's oesophageal adenocarcinoma cells."xsd:string |
| http://purl.uniprot.org/citations/18771702 | http://purl.uniprot.org/core/volume | "296"xsd:string |
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