| http://purl.uniprot.org/citations/18772112 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18772112 | http://www.w3.org/2000/01/rdf-schema#comment | "In intestinal epithelial cells, inactivation of APC, a key regulator of the Wnt pathway, activates beta-catenin to initiate tumorigenesis. However, other alterations may be involved in intestinal tumorigenesis. Here we found that RUNX3, a gastric tumor suppressor, forms a ternary complex with beta-catenin/TCF4 and attenuates Wnt signaling activity. A significant fraction of human sporadic colorectal adenomas and Runx3(+/-) mouse intestinal adenomas showed inactivation of RUNX3 without apparent beta-catenin accumulation, indicating that RUNX3 inactivation independently induces intestinal adenomas. In human colon cancers, RUNX3 is frequently inactivated with concomitant beta-catenin accumulation, suggesting that adenomas induced by inactivation of RUNX3 may progress to malignancy. Taken together, these data demonstrate that RUNX3 functions as a tumor suppressor by attenuating Wnt signaling."xsd:string |
| http://purl.uniprot.org/citations/18772112 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ccr.2008.08.004"xsd:string |
| http://purl.uniprot.org/citations/18772112 | http://purl.uniprot.org/core/author | "Fukamachi H."xsd:string |
| http://purl.uniprot.org/citations/18772112 | http://purl.uniprot.org/core/author | "Ito Y."xsd:string |
| http://purl.uniprot.org/citations/18772112 | http://purl.uniprot.org/core/author | "Ito K."xsd:string |
| http://purl.uniprot.org/citations/18772112 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/18772112 | http://purl.uniprot.org/core/author | "Lee C.W."xsd:string |
| http://purl.uniprot.org/citations/18772112 | http://purl.uniprot.org/core/author | "Lim A.C."xsd:string |
| http://purl.uniprot.org/citations/18772112 | http://purl.uniprot.org/core/author | "Osato M."xsd:string |
| http://purl.uniprot.org/citations/18772112 | http://purl.uniprot.org/core/author | "Chuang L.S."xsd:string |
| http://purl.uniprot.org/citations/18772112 | http://purl.uniprot.org/core/author | "Salto-Tellez M."xsd:string |
| http://purl.uniprot.org/citations/18772112 | http://purl.uniprot.org/core/author | "Voon D.C."xsd:string |
| http://purl.uniprot.org/citations/18772112 | http://purl.uniprot.org/core/author | "Motoda L."xsd:string |
| http://purl.uniprot.org/citations/18772112 | http://purl.uniprot.org/core/author | "Koo J.K."xsd:string |
| http://purl.uniprot.org/citations/18772112 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18772112 | http://purl.uniprot.org/core/name | "Cancer Cell"xsd:string |
| http://purl.uniprot.org/citations/18772112 | http://purl.uniprot.org/core/pages | "226-237"xsd:string |
| http://purl.uniprot.org/citations/18772112 | http://purl.uniprot.org/core/title | "RUNX3 attenuates beta-catenin/T cell factors in intestinal tumorigenesis."xsd:string |
| http://purl.uniprot.org/citations/18772112 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/18772112 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18772112 |
| http://purl.uniprot.org/citations/18772112 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18772112 |
| http://purl.uniprot.org/uniprot/#_B4DVE5-mappedCitation-18772112 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18772112 |
| http://purl.uniprot.org/uniprot/#_A1A549-mappedCitation-18772112 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18772112 |
| http://purl.uniprot.org/uniprot/#_A1A550-mappedCitation-18772112 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18772112 |