| http://purl.uniprot.org/citations/18772881 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18772881 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18772881 | http://www.w3.org/2000/01/rdf-schema#comment | "Immunoglobulin genes are generated somatically through specialized mechanisms resulting in a vast repertoire of antigen-binding sites. Despite the stochastic nature of these processes, the V-genes that encode most of the antigen-combining site are under positive evolutionary selection, raising the possibility that V-genes have been selected to encode key structural features of binding sites of protective antibodies against certain pathogens. Human, neutralizing antibodies to human cytomegalovirus that bind the AD-2S1 epitope on its gB envelope protein repeatedly use a pair of well-conserved, germline V-genes IGHV3-30 and IGKV3-11. Here, we present crystallographic, kinetic and thermodynamic analyses of the binding site of such an antibody and that of its primary immunoglobulin ancestor. These show that these germline V-genes encode key side chain contacts with the viral antigen and thereby dictate key structural features of the hypermutated, high-affinity neutralizing antibody. V-genes may thus encode an innate, protective immunological memory that targets vulnerable, invariant sites on multiple pathogens."xsd:string |
| http://purl.uniprot.org/citations/18772881 | http://purl.org/dc/terms/identifier | "doi:10.1038/emboj.2008.179"xsd:string |
| http://purl.uniprot.org/citations/18772881 | http://purl.org/dc/terms/identifier | "doi:10.1038/emboj.2008.179"xsd:string |
| http://purl.uniprot.org/citations/18772881 | http://purl.uniprot.org/core/author | "Pai E.F."xsd:string |
| http://purl.uniprot.org/citations/18772881 | http://purl.uniprot.org/core/author | "Pai E.F."xsd:string |
| http://purl.uniprot.org/citations/18772881 | http://purl.uniprot.org/core/author | "Creagh A.L."xsd:string |
| http://purl.uniprot.org/citations/18772881 | http://purl.uniprot.org/core/author | "Creagh A.L."xsd:string |
| http://purl.uniprot.org/citations/18772881 | http://purl.uniprot.org/core/author | "Bryson S."xsd:string |
| http://purl.uniprot.org/citations/18772881 | http://purl.uniprot.org/core/author | "Bryson S."xsd:string |
| http://purl.uniprot.org/citations/18772881 | http://purl.uniprot.org/core/author | "McLean G.R."xsd:string |
| http://purl.uniprot.org/citations/18772881 | http://purl.uniprot.org/core/author | "McLean G.R."xsd:string |
| http://purl.uniprot.org/citations/18772881 | http://purl.uniprot.org/core/author | "Schrader J.W."xsd:string |
| http://purl.uniprot.org/citations/18772881 | http://purl.uniprot.org/core/author | "Schrader J.W."xsd:string |
| http://purl.uniprot.org/citations/18772881 | http://purl.uniprot.org/core/author | "Thomson C.A."xsd:string |
| http://purl.uniprot.org/citations/18772881 | http://purl.uniprot.org/core/author | "Thomson C.A."xsd:string |
| http://purl.uniprot.org/citations/18772881 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18772881 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18772881 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/18772881 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/18772881 | http://purl.uniprot.org/core/pages | "2592-2602"xsd:string |
| http://purl.uniprot.org/citations/18772881 | http://purl.uniprot.org/core/pages | "2592-2602"xsd:string |
| http://purl.uniprot.org/citations/18772881 | http://purl.uniprot.org/core/title | "Germline V-genes sculpt the binding site of a family of antibodies neutralizing human cytomegalovirus."xsd:string |
| http://purl.uniprot.org/citations/18772881 | http://purl.uniprot.org/core/title | "Germline V-genes sculpt the binding site of a family of antibodies neutralizing human cytomegalovirus."xsd:string |