Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/18774388http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/18774388http://www.w3.org/2000/01/rdf-schema#comment"

Background

Eight genes in the immune signaling pathway shown to be differentially expressed in asthmatic lung biopsy specimens in a previous microarray experiment were selected as candidate genes for asthma susceptibility.

Objective

We sought to perform an association study with these genes and asthma-related phenotypes in 3 independent Canadian familial asthma collections and 1 Australian asthma case-control study.

Methods

Tagging single nucleotide polymorphisms were selected by using the HapMap public database (r(2) > 0.8; minor allele frequency >0.10) and genotyped with the Illumina platform. Family-based association and trend tests for asthma, atopy, airway hyperresponsiveness, and allergic asthma phenotypes were done in each sample, correcting for multiple testing.

Results

Uncorrected associations with polymorphisms within 7 genes were detected with 1 or more of the phenotypes in 1 or more of the 4 populations (.001

ConclusionExpression profiling studies are a useful way to identify candidate genes for asthma because this approach has led to the first report of an association with 15-LO in 2 independent populations. Because 15-LO is involved in anti-inflammatory processes, further functional and clinical investigation of the role of this biologic pathway in asthma is warranted."xsd:string

http://purl.uniprot.org/citations/18774388http://purl.org/dc/terms/identifier"doi:10.1016/j.jaci.2008.05.049"xsd:string
http://purl.uniprot.org/citations/18774388http://purl.uniprot.org/core/author"Becker A."xsd:string
http://purl.uniprot.org/citations/18774388http://purl.uniprot.org/core/author"Hudson T.J."xsd:string
http://purl.uniprot.org/citations/18774388http://purl.uniprot.org/core/author"James A.L."xsd:string
http://purl.uniprot.org/citations/18774388http://purl.uniprot.org/core/author"Musk A.W."xsd:string
http://purl.uniprot.org/citations/18774388http://purl.uniprot.org/core/author"Chamberland A."xsd:string
http://purl.uniprot.org/citations/18774388http://purl.uniprot.org/core/author"Montpetit A."xsd:string
http://purl.uniprot.org/citations/18774388http://purl.uniprot.org/core/author"Lemire M."xsd:string
http://purl.uniprot.org/citations/18774388http://purl.uniprot.org/core/author"Tremblay K."xsd:string
http://purl.uniprot.org/citations/18774388http://purl.uniprot.org/core/author"Laviolette M."xsd:string
http://purl.uniprot.org/citations/18774388http://purl.uniprot.org/core/author"Laprise C."xsd:string
http://purl.uniprot.org/citations/18774388http://purl.uniprot.org/core/author"Daley D."xsd:string
http://purl.uniprot.org/citations/18774388http://purl.uniprot.org/core/author"Pare P.D."xsd:string
http://purl.uniprot.org/citations/18774388http://purl.uniprot.org/core/author"Sandford A.J."xsd:string
http://purl.uniprot.org/citations/18774388http://purl.uniprot.org/core/author"Chan-Yeung M."xsd:string
http://purl.uniprot.org/citations/18774388http://purl.uniprot.org/core/author"Kozyrskyj A.L."xsd:string
http://purl.uniprot.org/citations/18774388http://purl.uniprot.org/core/date"2008"xsd:gYear
http://purl.uniprot.org/citations/18774388http://purl.uniprot.org/core/name"J Allergy Clin Immunol"xsd:string
http://purl.uniprot.org/citations/18774388http://purl.uniprot.org/core/pages"529-36.e17"xsd:string
http://purl.uniprot.org/citations/18774388http://purl.uniprot.org/core/title"Genetic variation in immune signaling genes differentially expressed in asthmatic lung tissues."xsd:string
http://purl.uniprot.org/citations/18774388http://purl.uniprot.org/core/volume"122"xsd:string
http://purl.uniprot.org/citations/18774388http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/18774388
http://purl.uniprot.org/citations/18774388http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/18774388
▶