| http://purl.uniprot.org/citations/18774778 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18774778 | http://www.w3.org/2000/01/rdf-schema#comment | "Although reactive oxygen species have been implicated as mediators of gastrointestinal injury, their influence on the function of gastric epithelial tight junctions (TJs), which create a paracellular permeability barrier, needs to be fully investigated. H2O2 exposure to MKN28 gastric epithelial monolayers caused a significant decrease in trans-epithelial electrical resistance (TEER) and a significant increase in dextran permeability. Oxidant-mediated gastric epithelial permeability was significantly attenuated by a radical scavenger, rebamipide. H2O2 decreased the amount of claudin-3 protein but not claudin-4, -7, and JAM-A. Rebamipide significantly attenuated H2O2-induced decrease in claudin-3 protein. Small interfering RNA (siRNA) against claudin-3 treatment specifically decreased claudin-3 as seen by immunoblotting and immunofluorescent staining. Gastric TEER was significantly decreased with the treatment of siRNA against claudin-3. This is the first study to demonstrate that claudin-3 is involved in the barrier function of gastric epithelial cells and that rebamipide abolishes the H2O2-induced decrease in claudin-3 protein."xsd:string |
| http://purl.uniprot.org/citations/18774778 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2008.08.140"xsd:string |
| http://purl.uniprot.org/citations/18774778 | http://purl.uniprot.org/core/author | "Kim Y."xsd:string |
| http://purl.uniprot.org/citations/18774778 | http://purl.uniprot.org/core/author | "Hashimoto K."xsd:string |
| http://purl.uniprot.org/citations/18774778 | http://purl.uniprot.org/core/author | "Matsumoto T."xsd:string |
| http://purl.uniprot.org/citations/18774778 | http://purl.uniprot.org/core/author | "Oshima T."xsd:string |
| http://purl.uniprot.org/citations/18774778 | http://purl.uniprot.org/core/author | "Tomita T."xsd:string |
| http://purl.uniprot.org/citations/18774778 | http://purl.uniprot.org/core/author | "Joh T."xsd:string |
| http://purl.uniprot.org/citations/18774778 | http://purl.uniprot.org/core/author | "Miwa H."xsd:string |
| http://purl.uniprot.org/citations/18774778 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18774778 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/18774778 | http://purl.uniprot.org/core/pages | "154-157"xsd:string |
| http://purl.uniprot.org/citations/18774778 | http://purl.uniprot.org/core/title | "Oxidative stress induces gastric epithelial permeability through claudin-3."xsd:string |
| http://purl.uniprot.org/citations/18774778 | http://purl.uniprot.org/core/volume | "376"xsd:string |
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