| http://purl.uniprot.org/citations/18775424 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18775424 | http://www.w3.org/2000/01/rdf-schema#comment | "Gap junctions (GJ) are required for mammary epithelial differentiation. Using epithelial (SCp2) and myoepithelial-like (SCg6) mouse-derived mammary cells, the role of heterocellular interaction in assembly of GJ complexes and functional differentiation (beta-casein expression) was evaluated. Heterocellular interaction is critical for beta-casein expression, independent of exogenous basement membrane or cell anchoring substrata. Functional differentiation of SCp2, co-cultured with SCg6, is more sensitive to GJ inhibition relative to homocellular SCp2 cultures differentiated by exogenous basement membrane. Connexin (Cx)32 and Cx43 levels were not regulated across culture conditions; however, GJ functionality was enhanced under differentiation-permissive conditions. Immunoprecipitation studies demonstrated association of junctional complex components (alpha-catenin, beta-catenin and ZO-2) with Cx32 and Cx43, in differentiation conditions, and additionally with Cx30 in heterocellular cultures. Although beta-catenin did not shuttle between cadherin and GJ complexes, increased association between connexins and beta-catenin in heterocellular cultures was observed. This was concomitant with reduced nuclear beta-catenin, suggesting that differentiation in heterocellular cultures involves sequestration of beta-catenin in GJ complexes."xsd:string |
| http://purl.uniprot.org/citations/18775424 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.yexcr.2008.07.030"xsd:string |
| http://purl.uniprot.org/citations/18775424 | http://purl.uniprot.org/core/author | "Khalil A."xsd:string |
| http://purl.uniprot.org/citations/18775424 | http://purl.uniprot.org/core/author | "Ismail A."xsd:string |
| http://purl.uniprot.org/citations/18775424 | http://purl.uniprot.org/core/author | "Abi-Mosleh L."xsd:string |
| http://purl.uniprot.org/citations/18775424 | http://purl.uniprot.org/core/author | "Talhouk R.S."xsd:string |
| http://purl.uniprot.org/citations/18775424 | http://purl.uniprot.org/core/author | "El-Sabban M.E."xsd:string |
| http://purl.uniprot.org/citations/18775424 | http://purl.uniprot.org/core/author | "Mokalled M."xsd:string |
| http://purl.uniprot.org/citations/18775424 | http://purl.uniprot.org/core/author | "Mroue R."xsd:string |
| http://purl.uniprot.org/citations/18775424 | http://purl.uniprot.org/core/author | "Nehme R."xsd:string |
| http://purl.uniprot.org/citations/18775424 | http://purl.uniprot.org/core/author | "Zaatari M."xsd:string |
| http://purl.uniprot.org/citations/18775424 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18775424 | http://purl.uniprot.org/core/name | "Exp Cell Res"xsd:string |
| http://purl.uniprot.org/citations/18775424 | http://purl.uniprot.org/core/pages | "3275-3291"xsd:string |
| http://purl.uniprot.org/citations/18775424 | http://purl.uniprot.org/core/title | "Heterocellular interaction enhances recruitment of alpha and beta-catenins and ZO-2 into functional gap-junction complexes and induces gap junction-dependant differentiation of mammary epithelial cells."xsd:string |
| http://purl.uniprot.org/citations/18775424 | http://purl.uniprot.org/core/volume | "314"xsd:string |
| http://purl.uniprot.org/citations/18775424 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18775424 |
| http://purl.uniprot.org/citations/18775424 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18775424 |
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| http://purl.uniprot.org/uniprot/#_D3Z5Q1-mappedCitation-18775424 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18775424 |
| http://purl.uniprot.org/uniprot/#_E9Q6A9-mappedCitation-18775424 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18775424 |
| http://purl.uniprot.org/uniprot/#_A0A494BA24-mappedCitation-18775424 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18775424 |
| http://purl.uniprot.org/uniprot/#_F7CRC6-mappedCitation-18775424 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18775424 |