| http://purl.uniprot.org/citations/18775916 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18775916 | http://www.w3.org/2000/01/rdf-schema#comment | "Insulin-like growth factor-binding protein-5 (IGFBP-5) is one of the six members of IGFBP family, important for cell growth control, induction of apoptosis and other IGF-stimulated signaling pathways. In this study, we focused on characterizing the specific function of IGFBP-5 as novel antiangiostatic factor. Overexpression of IGFBP-5 suppressed the tube formation as well as the biological functions of angiostatic activity in vivo. This result is due to the reduced expressions of phosphorylated protein kinase B and phosphorylated endothelial NO synthase, which plays important roles in the regulation of angiogenesis when stimulated by vascular endothelial growth factor. Further, IGFBP-5 expression prevented tumor growth and inhibited tumor vascularity in a xenograft model of human ovarian cancer. These results are the first evidence showing that IGFBP-5 plays a role as tumor suppressor by inhibiting angiogenesis."xsd:string |
| http://purl.uniprot.org/citations/18775916 | http://purl.org/dc/terms/identifier | "doi:10.1093/carcin/bgn206"xsd:string |
| http://purl.uniprot.org/citations/18775916 | http://purl.uniprot.org/core/author | "Kang S."xsd:string |
| http://purl.uniprot.org/citations/18775916 | http://purl.uniprot.org/core/author | "Park S.Y."xsd:string |
| http://purl.uniprot.org/citations/18775916 | http://purl.uniprot.org/core/author | "Woo J.S."xsd:string |
| http://purl.uniprot.org/citations/18775916 | http://purl.uniprot.org/core/author | "Rho S.B."xsd:string |
| http://purl.uniprot.org/citations/18775916 | http://purl.uniprot.org/core/author | "Dong S.M."xsd:string |
| http://purl.uniprot.org/citations/18775916 | http://purl.uniprot.org/core/author | "Seo S.S."xsd:string |
| http://purl.uniprot.org/citations/18775916 | http://purl.uniprot.org/core/author | "Lee D.O."xsd:string |
| http://purl.uniprot.org/citations/18775916 | http://purl.uniprot.org/core/author | "Yoo C.W."xsd:string |
| http://purl.uniprot.org/citations/18775916 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18775916 | http://purl.uniprot.org/core/name | "Carcinogenesis"xsd:string |
| http://purl.uniprot.org/citations/18775916 | http://purl.uniprot.org/core/pages | "2106-2111"xsd:string |
| http://purl.uniprot.org/citations/18775916 | http://purl.uniprot.org/core/title | "Insulin-like growth factor-binding protein-5 (IGFBP-5) acts as a tumor suppressor by inhibiting angiogenesis."xsd:string |
| http://purl.uniprot.org/citations/18775916 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/18775916 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18775916 |
| http://purl.uniprot.org/citations/18775916 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18775916 |
| http://purl.uniprot.org/uniprot/#_P24593-mappedCitation-18775916 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18775916 |
| http://purl.uniprot.org/uniprot/#_Q8WV97-mappedCitation-18775916 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18775916 |
| http://purl.uniprot.org/uniprot/#_Q96HT5-mappedCitation-18775916 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18775916 |
| http://purl.uniprot.org/uniprot/Q8WV97 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18775916 |
| http://purl.uniprot.org/uniprot/P24593 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18775916 |
| http://purl.uniprot.org/uniprot/Q96HT5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18775916 |