| http://purl.uniprot.org/citations/18780835 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18780835 | http://www.w3.org/2000/01/rdf-schema#comment | "HIV-1 infection is associated with B-cell abnormalities, such as hypergammaglobulinemia, poor immunization responses, and loss of serologic memory. To determine whether altered expression of chemokine receptors and their ligands may play a role in B-cell dysfunctions during HIV-1 infection, the expression of CXC chemokine receptor 4 (CXCR4), CXCR5, and CC chemokine receptor 7 (CCR7) and their respective ligands on CD19(+) B cells were examined in HIV-1-infected patients and controls. We report a decreased CXCR5 expression on B cells from patients (P < .05), a phenomenon associated with a low CD4 T-cell count (< 350 cells/microL). Interestingly, an increased expression of CXC chemokine ligand 13 (CXCL13), the ligand for CXCR5, was found in peripheral B cells from HIV-1-infected patients. Moreover, on B-cell activation in vitro, CXCL13 was secreted in culture. CXCL13(+) B cells were also found in the lymph nodes of HIV-1-infected patients, but not in control tissue. B-cell migration toward CXCL13, CXCL12, and CC chemokine ligand 21 (CCL21), ligands for CXCR5, CXCR4, and CCR7 was also evaluated. In patients with a low CD4 T-cell count, migration toward all ligands was increased. Our findings indicate that altered expression of the chemokine receptor-ligand pair, CXCR5/CXCL13, may participate in the establishment of B-cell dysfunctions during HIV-1 infection."xsd:string |
| http://purl.uniprot.org/citations/18780835 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2008-02-140426"xsd:string |
| http://purl.uniprot.org/citations/18780835 | http://purl.uniprot.org/core/author | "Nilsson A."xsd:string |
| http://purl.uniprot.org/citations/18780835 | http://purl.uniprot.org/core/author | "Chiodi F."xsd:string |
| http://purl.uniprot.org/citations/18780835 | http://purl.uniprot.org/core/author | "Grutzmeier S."xsd:string |
| http://purl.uniprot.org/citations/18780835 | http://purl.uniprot.org/core/author | "Racz P."xsd:string |
| http://purl.uniprot.org/citations/18780835 | http://purl.uniprot.org/core/author | "Cagigi A."xsd:string |
| http://purl.uniprot.org/citations/18780835 | http://purl.uniprot.org/core/author | "Tenner-Racz K."xsd:string |
| http://purl.uniprot.org/citations/18780835 | http://purl.uniprot.org/core/author | "Atlas A."xsd:string |
| http://purl.uniprot.org/citations/18780835 | http://purl.uniprot.org/core/author | "Mowafi F."xsd:string |
| http://purl.uniprot.org/citations/18780835 | http://purl.uniprot.org/core/author | "Phuong Dang L.V."xsd:string |
| http://purl.uniprot.org/citations/18780835 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18780835 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/18780835 | http://purl.uniprot.org/core/pages | "4401-4410"xsd:string |
| http://purl.uniprot.org/citations/18780835 | http://purl.uniprot.org/core/title | "Altered expression of the receptor-ligand pair CXCR5/CXCL13 in B cells during chronic HIV-1 infection."xsd:string |
| http://purl.uniprot.org/citations/18780835 | http://purl.uniprot.org/core/volume | "112"xsd:string |
| http://purl.uniprot.org/citations/18780835 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18780835 |
| http://purl.uniprot.org/citations/18780835 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18780835 |
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| http://purl.uniprot.org/uniprot/#_Q53X90-mappedCitation-18780835 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18780835 |
| http://purl.uniprot.org/uniprot/#_P32302-mappedCitation-18780835 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18780835 |
| http://purl.uniprot.org/uniprot/#_Q2YD84-mappedCitation-18780835 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18780835 |