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http://purl.uniprot.org/citations/18782112http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/18782112http://www.w3.org/2000/01/rdf-schema#comment"

Background

Allergic rhinitis (AR) is characterized by Th2-polarized immune response. Soluble HLA (sHLA) molecules play an immunomodulatory activity. So far, however, no study investigated them in AR.

Objective

The aim of this study was to evaluate sHLA-G and sHLA-A,-B,-C serum levels in AR patients with pollen allergy and in a group of healthy controls.

Methods

Forty-nine AR patients were enrolled. A group of healthy nonallergic subjects was considered as control. sHLA-G and sHLA-A,-B,-C serum levels were determined by immunoenzymatic method. The study was conducted during the winter, such as outside the pollen season.

Results

Allergic patients had significantly higher levels of both sHLA-G (P < 0.0001) and sHLA-A,-B,-C (P = 0.011) molecules than normal controls. Moreover, there was a significant relationship between these two soluble molecules (r = 0.69) in allergic patients.

Conclusion

The present study provides the first evidence that both sHLA-G and sHLA-A,-B,-C serum levels are significantly increased in AR patients with pollen allergy."xsd:string
http://purl.uniprot.org/citations/18782112http://purl.org/dc/terms/identifier"doi:10.1111/j.1398-9995.2008.01741.x"xsd:string
http://purl.uniprot.org/citations/18782112http://purl.uniprot.org/core/author"Puppo F."xsd:string
http://purl.uniprot.org/citations/18782112http://purl.uniprot.org/core/author"Pistorio A."xsd:string
http://purl.uniprot.org/citations/18782112http://purl.uniprot.org/core/author"Colombo B.M."xsd:string
http://purl.uniprot.org/citations/18782112http://purl.uniprot.org/core/author"Contini P."xsd:string
http://purl.uniprot.org/citations/18782112http://purl.uniprot.org/core/author"Murdaca G."xsd:string
http://purl.uniprot.org/citations/18782112http://purl.uniprot.org/core/author"Ciprandi G."xsd:string
http://purl.uniprot.org/citations/18782112http://purl.uniprot.org/core/author"Cagnati P."xsd:string
http://purl.uniprot.org/citations/18782112http://purl.uniprot.org/core/date"2008"xsd:gYear
http://purl.uniprot.org/citations/18782112http://purl.uniprot.org/core/name"Allergy"xsd:string
http://purl.uniprot.org/citations/18782112http://purl.uniprot.org/core/pages"1335-1338"xsd:string
http://purl.uniprot.org/citations/18782112http://purl.uniprot.org/core/title"Soluble HLA-G and HLA-A,-B,-C serum levels in patients with allergic rhinitis."xsd:string
http://purl.uniprot.org/citations/18782112http://purl.uniprot.org/core/volume"63"xsd:string
http://purl.uniprot.org/citations/18782112http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/18782112
http://purl.uniprot.org/citations/18782112http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/18782112
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http://purl.uniprot.org/uniprot/#_A0A0A7C552-mappedCitation-18782112http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18782112
http://purl.uniprot.org/uniprot/#_A0A0A7C553-mappedCitation-18782112http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18782112
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