| http://purl.uniprot.org/citations/18782567 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18782567 | http://www.w3.org/2000/01/rdf-schema#comment | "Lung adenocarcinoma Cl1-5 cells were selected from parental Cl1-0 cells based on their high metastatic potential. In a previous study, CRMP-1, an invasion suppressor gene, was shown to be suppressed in Cl1-5 cells. However, the regulation of CRMP-1 expression has not been explored. In this study, we showed nuclear factor-kappaB controls CRMP-1 expression. The electromobility shift assay showed that while Cl1-0 cells exhibited low NF-kappaB activity in response to TNF-alpha, an abundance of basal and TNF-alpha-induced NF-kappaB-DNA complex was detected in Cl1-5 cells. Supershift-coupled EMSA and Western blotting of nuclear proteins, however, revealed p50 protein, but not classic p65/p50 heterodimer in the complex. ChIP and EMSA demonstrated that p50 binds to a kappaB site residing between -1753 and -1743 of the CRMP-1 promoter region. Transfection of antisense p50 gene into Cl1-5 cells increased the CRMP-1 protein level and decreased the invasive activity of Cl1-5 cells."xsd:string |
| http://purl.uniprot.org/citations/18782567 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2008.08.144"xsd:string |
| http://purl.uniprot.org/citations/18782567 | http://purl.uniprot.org/core/author | "Gao M."xsd:string |
| http://purl.uniprot.org/citations/18782567 | http://purl.uniprot.org/core/author | "Chang W.C."xsd:string |
| http://purl.uniprot.org/citations/18782567 | http://purl.uniprot.org/core/author | "Kuo M.L."xsd:string |
| http://purl.uniprot.org/citations/18782567 | http://purl.uniprot.org/core/author | "Cheng A.L."xsd:string |
| http://purl.uniprot.org/citations/18782567 | http://purl.uniprot.org/core/author | "Yeh P.Y."xsd:string |
| http://purl.uniprot.org/citations/18782567 | http://purl.uniprot.org/core/author | "Lu Y.S."xsd:string |
| http://purl.uniprot.org/citations/18782567 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18782567 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/18782567 | http://purl.uniprot.org/core/pages | "283-287"xsd:string |
| http://purl.uniprot.org/citations/18782567 | http://purl.uniprot.org/core/title | "NF-kappaB p50 promotes tumor cell invasion through negative regulation of invasion suppressor gene CRMP-1 in human lung adenocarcinoma cells."xsd:string |
| http://purl.uniprot.org/citations/18782567 | http://purl.uniprot.org/core/volume | "376"xsd:string |
| http://purl.uniprot.org/citations/18782567 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18782567 |
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