| http://purl.uniprot.org/citations/18787100 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18787100 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18787100 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin (IL)-33 is a novel member of the IL-1 family of cytokines that promotes Th2 responses in lymphocytes as well as the activation of both mast cells and eosinophils via the ST2 receptor. Additionally, IL-33 has been proposed to act as a chromatin-associated transcriptional regulator in both endothelial cells of high endothelial venules and chronically inflamed vessels. Here we show that nuclear IL-33 is expressed in blood vessels of healthy tissues but down-regulated at the earliest onset of angiogenesis during wound healing; in addition, it is almost undetectable in human tumor vessels. Accordingly, IL-33 is induced when cultured endothelial cells reach confluence and stop proliferating but is lost when these cells begin to migrate. However, IL-33 expression was not induced by inhibiting cell cycle progression in subconfluent cultures and was not prevented by antibody-mediated inhibition of VE-cadherin. Conversely, IL-33 knockdown did not induce detectable changes in either expression levels or the cellular distribution of either VE-cadherin or CD31. However, activation of endothelial cell cultures with either tumor necrosis factor-alpha or vascular endothelial growth factor and subcutaneous injection of these cytokines led to a down-regulation of vascular IL-33, a response consistent with both its rapid down-regulation in wound healing and loss in tumor endothelium. In conclusion, we speculate that the proposed transcriptional repressor function of IL-33 may be involved in the control of endothelial cell activation."xsd:string |
| http://purl.uniprot.org/citations/18787100 | http://purl.org/dc/terms/identifier | "doi:10.2353/ajpath.2008.080014"xsd:string |
| http://purl.uniprot.org/citations/18787100 | http://purl.org/dc/terms/identifier | "doi:10.2353/ajpath.2008.080014"xsd:string |
| http://purl.uniprot.org/citations/18787100 | http://purl.uniprot.org/core/author | "De Angelis P.M."xsd:string |
| http://purl.uniprot.org/citations/18787100 | http://purl.uniprot.org/core/author | "De Angelis P.M."xsd:string |
| http://purl.uniprot.org/citations/18787100 | http://purl.uniprot.org/core/author | "Haraldsen G."xsd:string |
| http://purl.uniprot.org/citations/18787100 | http://purl.uniprot.org/core/author | "Haraldsen G."xsd:string |
| http://purl.uniprot.org/citations/18787100 | http://purl.uniprot.org/core/author | "Scott H."xsd:string |
| http://purl.uniprot.org/citations/18787100 | http://purl.uniprot.org/core/author | "Scott H."xsd:string |
| http://purl.uniprot.org/citations/18787100 | http://purl.uniprot.org/core/author | "Balogh J."xsd:string |
| http://purl.uniprot.org/citations/18787100 | http://purl.uniprot.org/core/author | "Balogh J."xsd:string |
| http://purl.uniprot.org/citations/18787100 | http://purl.uniprot.org/core/author | "Kuchler A.M."xsd:string |
| http://purl.uniprot.org/citations/18787100 | http://purl.uniprot.org/core/author | "Kuchler A.M."xsd:string |
| http://purl.uniprot.org/citations/18787100 | http://purl.uniprot.org/core/author | "Manley L."xsd:string |
| http://purl.uniprot.org/citations/18787100 | http://purl.uniprot.org/core/author | "Manley L."xsd:string |
| http://purl.uniprot.org/citations/18787100 | http://purl.uniprot.org/core/author | "Pollheimer J."xsd:string |
| http://purl.uniprot.org/citations/18787100 | http://purl.uniprot.org/core/author | "Pollheimer J."xsd:string |
| http://purl.uniprot.org/citations/18787100 | http://purl.uniprot.org/core/author | "Sorensen D.R."xsd:string |
| http://purl.uniprot.org/citations/18787100 | http://purl.uniprot.org/core/author | "Sorensen D.R."xsd:string |
| http://purl.uniprot.org/citations/18787100 | http://purl.uniprot.org/core/author | "Sponheim J."xsd:string |
| http://purl.uniprot.org/citations/18787100 | http://purl.uniprot.org/core/author | "Sponheim J."xsd:string |
| http://purl.uniprot.org/citations/18787100 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18787100 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |