| http://purl.uniprot.org/citations/18788572 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18788572 | http://www.w3.org/2000/01/rdf-schema#comment | "ObjectiveTo investigate the association of single nucleotide polymorphisms (SNP) in p21 and p27 genes with the risk of epithelial ovarian cancer (EOC).MethodsGenotypes were analyzed by polymerase chain reaction-restrictive fragment length polymorphism (PCR-RFLP) method in 234 patients with EOC and 284 control women in China.Results(1) The frequencies of the p21 in healthy controls were 34.2%, 49.6% and 16.2%, while the distribution of the C and T allele was 59.0% and 41.0%, respectively. The p21 C/C (28.2%), C/T (53.0%), T/T (18.8%) distribution in ovarian cancer patients was not significantly different from that in healthy controls (P > 0.05). There was no statistic difference in allele distribution between ovarian cancer patients and healthy controls (P > 0.05) either. The stratification analysis by tumor histological type did show that the genotype distribution in four types of ovarian cancer patients was significantly different from that in healthy controls (P = 0.02) . The C/C genotype was likely to reduce the risk of epithelial endometrial cancer, and the adjusted odds ratio was 0.56 (95% CI:0.32-0.98). (2) The genotype frequencies of the p27 in healthy controls were 88.4%, 10.9% and 0.7%, while the distribution of the V and G allele was 93.8% and 6.2%, respectively. The V/V (93.6%), V/G (5.1%) and G/G (1.3%) distribution in ovarian cancer patients was significantly different from that in healthy controls (P = 0. 04). There was no statistic difference in allele distribution between ovarian cancer patients and healthy controls (P > 0.05). Compared with the V/G and G/G genotypes, the V/V genotype increased the risk of EOC, the adjusted odds ratio was 1.92 (95% CI: 1.02-3.63).ConclusionThe C/C genotype of p21 may reduce the risk of epithelial endometrial cancer, and the genotype of p27 V/V may be a potential risk factor for susceptibility to EOC."xsd:string |
| http://purl.uniprot.org/citations/18788572 | http://purl.uniprot.org/core/author | "Kang S."xsd:string |
| http://purl.uniprot.org/citations/18788572 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/18788572 | http://purl.uniprot.org/core/author | "Wang N."xsd:string |
| http://purl.uniprot.org/citations/18788572 | http://purl.uniprot.org/core/author | "Jin X."xsd:string |
| http://purl.uniprot.org/citations/18788572 | http://purl.uniprot.org/core/author | "Xing Y.P."xsd:string |
| http://purl.uniprot.org/citations/18788572 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18788572 | http://purl.uniprot.org/core/name | "Zhonghua Fu Chan Ke Za Zhi"xsd:string |
| http://purl.uniprot.org/citations/18788572 | http://purl.uniprot.org/core/pages | "209-212"xsd:string |
| http://purl.uniprot.org/citations/18788572 | http://purl.uniprot.org/core/title | "[Single nucleotide polymorphisms in cell cycle regulator p21 and p27 genes are associated with susceptibility to epithelial ovarian cancer]."xsd:string |
| http://purl.uniprot.org/citations/18788572 | http://purl.uniprot.org/core/volume | "43"xsd:string |
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