| http://purl.uniprot.org/citations/18789440 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18789440 | http://www.w3.org/2000/01/rdf-schema#comment | "Interferon gamma (IFN-gamma) is an immunomodulatory and anti-microbial cytokine, which has a variety of proatherogenic effects. It has been reported that IFN-gamma can down-regulate ABCA1 expression. However, its mechanism is elusive. In the present study, we have investigated the effect of IFN-gamma on ABCA1 expression and cholesterol efflux in THP-1 macrophage-derived foam cells. IFN-gamma decreased ABCA1 expression at both transcriptional and translational levels in a dose-dependent manner. Cellular cholesterol content was increased while cholesterol efflux was decreased by IFN-gamma treatment. Liver X receptor alpha (LXRalpha), which can regulate the expression of ABCA1, was also down-regulated by IFN-gamma treatment. LXRalpha-specific activation by LXRalpha agonist almost compensated the down-regulation of ABCA1 expression by IFN-gamma, while siRNA of LXRalpha led to down-regulation of ABCA1 expression more significantly than IFN-gamma. IFN-gamma induced phosphorylation of STAT1 and expression of STAT1alpha in the nucleus, which was inhibited by a JAK inhibitor AG-490. Treatment with STAT1 siRNA further enhanced down-regulation of LXRalpha mRNA by IFN-gamma. Furthermore, AG-490 and STAT1 siRNA almost compensated the effect of IFN-gamma on ABCA1 expression and cholesterol efflux. In conclusion, IFN-gamma may first down-regulate expression of LXRalpha through the JAK/STAT1 signaling pathway and then decrease expression of ABCA1 and cholesterol efflux in THP-1 macrophage-derived foam cells. Therefore, our study may be useful in understanding the critical effect of IFN-gamma in pathogenesis of atherosclerosis."xsd:string |
| http://purl.uniprot.org/citations/18789440 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.atherosclerosis.2008.07.029"xsd:string |
| http://purl.uniprot.org/citations/18789440 | http://purl.uniprot.org/core/author | "Li X.X."xsd:string |
| http://purl.uniprot.org/citations/18789440 | http://purl.uniprot.org/core/author | "Xiao J."xsd:string |
| http://purl.uniprot.org/citations/18789440 | http://purl.uniprot.org/core/author | "Xiang J."xsd:string |
| http://purl.uniprot.org/citations/18789440 | http://purl.uniprot.org/core/author | "Tang C.K."xsd:string |
| http://purl.uniprot.org/citations/18789440 | http://purl.uniprot.org/core/author | "Liao D.F."xsd:string |
| http://purl.uniprot.org/citations/18789440 | http://purl.uniprot.org/core/author | "Liu X.H."xsd:string |
| http://purl.uniprot.org/citations/18789440 | http://purl.uniprot.org/core/author | "Hu Y.W."xsd:string |
| http://purl.uniprot.org/citations/18789440 | http://purl.uniprot.org/core/author | "Cao D.L."xsd:string |
| http://purl.uniprot.org/citations/18789440 | http://purl.uniprot.org/core/author | "Hao X.R."xsd:string |
| http://purl.uniprot.org/citations/18789440 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/18789440 | http://purl.uniprot.org/core/name | "Atherosclerosis"xsd:string |
| http://purl.uniprot.org/citations/18789440 | http://purl.uniprot.org/core/pages | "417-428"xsd:string |
| http://purl.uniprot.org/citations/18789440 | http://purl.uniprot.org/core/title | "IFN-gamma down-regulates ABCA1 expression by inhibiting LXRalpha in a JAK/STAT signaling pathway-dependent manner."xsd:string |
| http://purl.uniprot.org/citations/18789440 | http://purl.uniprot.org/core/volume | "203"xsd:string |
| http://purl.uniprot.org/citations/18789440 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18789440 |
| http://purl.uniprot.org/citations/18789440 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18789440 |
| http://purl.uniprot.org/uniprot/#_A0A0A0N0M2-mappedCitation-18789440 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18789440 |
| http://purl.uniprot.org/uniprot/#_A0A7R8GUN6-mappedCitation-18789440 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18789440 |
| http://purl.uniprot.org/uniprot/#_A0A8V8TPQ9-mappedCitation-18789440 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18789440 |
| http://purl.uniprot.org/uniprot/#_B7XCW9-mappedCitation-18789440 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18789440 |
| http://purl.uniprot.org/uniprot/#_A0A510GDC6-mappedCitation-18789440 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18789440 |
| http://purl.uniprot.org/uniprot/#_A5D905-mappedCitation-18789440 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18789440 |