| http://purl.uniprot.org/citations/18792400 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18792400 | http://www.w3.org/2000/01/rdf-schema#comment | "We recently reported that differentiation of CD8(+) T cells from the naïve to the effector state involves the upregulation of glucose-dependent metabolism. Glucose deprivation or inhibition of glycolysis by 2-deoxy-D-glucose (2-DG) selectively inhibited production of IFN-gamma but not of IL-2. To determine a more global role of glucose metabolism on effector T-cell function, we performed gene array analysis on CD8(+) effector T cells stimulated in the presence or absence of 2-DG. We observed that expression of only 10% of genes induced by TCR/CD28 signaling was inhibited by 2-DG. Among these were genes for key cytokines, cell cycle molecules, and cytotoxic granule proteins. Consistent with these results, production of IFN-gamma and GM-CSF, cell cycle progression, upregulation of cyclin D2 protein, cytolytic activity, and upregulation of granzyme B protein and also conjugate formation were exquisitely glucose-dependent. In contrast to glucose, oxygen was little utilized by CD8(+) effector T cells, and relative oxygen deprivation did not inhibit these CTL functional properties. Our results indicate a particularly critical role for glucose in regulating specific effector functions of CD8(+) T cells and have implications for the maintenance of the effector phase of cellular immune responses in target tissue microenvironments such as a solid tumor."xsd:string |
| http://purl.uniprot.org/citations/18792400 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.200838289"xsd:string |
| http://purl.uniprot.org/citations/18792400 | http://purl.uniprot.org/core/author | "Cham C.M."xsd:string |
| http://purl.uniprot.org/citations/18792400 | http://purl.uniprot.org/core/author | "Driessens G."xsd:string |
| http://purl.uniprot.org/citations/18792400 | http://purl.uniprot.org/core/author | "Gajewski T.F."xsd:string |
| http://purl.uniprot.org/citations/18792400 | http://purl.uniprot.org/core/author | "O'Keefe J.P."xsd:string |
| http://purl.uniprot.org/citations/18792400 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18792400 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/18792400 | http://purl.uniprot.org/core/pages | "2438-2450"xsd:string |
| http://purl.uniprot.org/citations/18792400 | http://purl.uniprot.org/core/title | "Glucose deprivation inhibits multiple key gene expression events and effector functions in CD8+ T cells."xsd:string |
| http://purl.uniprot.org/citations/18792400 | http://purl.uniprot.org/core/volume | "38"xsd:string |
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