| http://purl.uniprot.org/citations/18794338 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18794338 | http://www.w3.org/2000/01/rdf-schema#comment | "E-selectin binding to P-selectin glycoprotein ligand-1 (PSGL-1) can activate the beta(2) integrin lymphocyte function-associated antigen-1 by signaling through spleen tyrosine kinase (Syk). This signaling is independent of G alpha(i)-protein-coupled receptors, results in slow rolling, and promotes neutrophil recruitment to sites of inflammation. However, the signaling pathways linking E-selectin engagement of PSGL-1 to Syk activation are unknown. To test the role of Src family kinases and immunoreceptor tyrosine-based activating motif (ITAM)-containing adaptor proteins, we used different gene-deficient mice in flow chamber, intravital microscopy, and peritonitis studies. E-selectin-mediated phosphorylation of Syk and slow rolling was abolished in neutrophils from fgr(-/-) or hck(-/-) lyn(-/-) fgr(-/-) mice. Neutrophils from Tyrobp(-/-) Fcrg(-/-) mice lacking both DAP12 and FcRgamma were incapable of sustaining slow neutrophil rolling on E-selectin and intercellular adhesion molecule-1 and were unable to phosphorylate Syk and p38 MAPK. This defect was confirmed in vivo by using mixed chimeric mice. G alpha(i)-independent neutrophil recruitment into the inflamed peritoneal cavity was sharply suppressed in Tyrobp(-/-) Fcrg(-/-) mice. Our data demonstrate that an ITAM-dependent pathway involving the Src-family kinase Fgr and the ITAM-containing adaptor proteins DAP12 and FcRgamma is involved in the initial signaling events downstream of PSGL-1 that are required to initiate neutrophil slow rolling."xsd:string |
| http://purl.uniprot.org/citations/18794338 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20072660"xsd:string |
| http://purl.uniprot.org/citations/18794338 | http://purl.uniprot.org/core/author | "Lowell C.A."xsd:string |
| http://purl.uniprot.org/citations/18794338 | http://purl.uniprot.org/core/author | "Abram C.L."xsd:string |
| http://purl.uniprot.org/citations/18794338 | http://purl.uniprot.org/core/author | "Altman A."xsd:string |
| http://purl.uniprot.org/citations/18794338 | http://purl.uniprot.org/core/author | "Zarbock A."xsd:string |
| http://purl.uniprot.org/citations/18794338 | http://purl.uniprot.org/core/author | "Ley K."xsd:string |
| http://purl.uniprot.org/citations/18794338 | http://purl.uniprot.org/core/author | "Hundt M."xsd:string |
| http://purl.uniprot.org/citations/18794338 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18794338 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/18794338 | http://purl.uniprot.org/core/pages | "2339-2347"xsd:string |
| http://purl.uniprot.org/citations/18794338 | http://purl.uniprot.org/core/title | "PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcR gamma to induce slow leukocyte rolling."xsd:string |
| http://purl.uniprot.org/citations/18794338 | http://purl.uniprot.org/core/volume | "205"xsd:string |
| http://purl.uniprot.org/citations/18794338 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18794338 |
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