| http://purl.uniprot.org/citations/18794532 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18794532 | http://www.w3.org/2000/01/rdf-schema#comment | "Timely interaction between the egg and sperm is required for successful fertilization; however, little is known about the signaling therein. Prostaglandin (PG) E receptor EP2-deficient (Ptger2(-/-)) female mice exhibit a severe fertilization defect. We investigated the molecular events leading to this failure. We found increased gene expression for chemokines, such as Ccl2, Ccl7, and Ccl9, in Ptger2(-/-) cumulus cells (the somatic cells surrounding the egg) compared with wild-type cells. Furthermore, under physiological conditions, cumulus-derived chemokine signaling was found to have a dual action; CCL7 facilitates sperm migration to the cumulus-egg complex and integrin-mediated cumulus extracellular matrix (ECM) assembly to protect eggs. However, in the absence of PGE(2)-EP2 signaling, chronic CCL7 signaling results in excessive integrin engagement to the ECM, making the cumulus ECM resistant to sperm hyaluronidase, thereby preventing sperm penetration. Our findings indicate that PGE(2)-EP2 signaling negatively regulates the autocrine action of chemokines and prevents excessive cumulus ECM assembly. This interaction between PG and chemokine signaling is required for successful fertilization."xsd:string |
| http://purl.uniprot.org/citations/18794532 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0805699105"xsd:string |
| http://purl.uniprot.org/citations/18794532 | http://purl.uniprot.org/core/author | "Narumiya S."xsd:string |
| http://purl.uniprot.org/citations/18794532 | http://purl.uniprot.org/core/author | "Sugimoto Y."xsd:string |
| http://purl.uniprot.org/citations/18794532 | http://purl.uniprot.org/core/author | "Ichikawa A."xsd:string |
| http://purl.uniprot.org/citations/18794532 | http://purl.uniprot.org/core/author | "Tamba S."xsd:string |
| http://purl.uniprot.org/citations/18794532 | http://purl.uniprot.org/core/author | "Segi-Nishida E."xsd:string |
| http://purl.uniprot.org/citations/18794532 | http://purl.uniprot.org/core/author | "Yodoi R."xsd:string |
| http://purl.uniprot.org/citations/18794532 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18794532 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/18794532 | http://purl.uniprot.org/core/pages | "14539-14544"xsd:string |
| http://purl.uniprot.org/citations/18794532 | http://purl.uniprot.org/core/title | "Timely interaction between prostaglandin and chemokine signaling is a prerequisite for successful fertilization."xsd:string |
| http://purl.uniprot.org/citations/18794532 | http://purl.uniprot.org/core/volume | "105"xsd:string |
| http://purl.uniprot.org/citations/18794532 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18794532 |
| http://purl.uniprot.org/citations/18794532 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18794532 |
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