| http://purl.uniprot.org/citations/18799618 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18799618 | http://www.w3.org/2000/01/rdf-schema#comment | "Members of the Snail family of transcription factors have been shown to induce epithelial-mesenchymal transition (EMT), a fundamental mechanism of embryogenesis and progressive disease. Here, we show that Snail and Slug promote formation of beta-catenin-T-cell factor (TCF)-4 transcription complexes that bind to the promoter of the TGF-beta3 gene to increase its transcription. Subsequent transforming growth factor (TGF)-beta3 signaling increases LEF-1 gene expression causing formation of beta-catenin-lymphoid enhancer factor (LEF)-1 complexes that initiate EMT. TGF-beta1 or TGF-beta2 stimulates this signaling mechanism by up-regulating synthesis of Snail and Slug. TGF-beta1- and TGF-beta2-induced EMT were found to be TGF-beta3 dependent, establishing essential roles for multiple TGF-beta isoforms. Finally, we determined that beta-catenin-LEF-1 complexes can promote EMT without upstream signaling pathways. These findings provide evidence for a unified signaling mechanism driven by convergence of multiple TGF-beta and TCF signaling molecules that confers loss of cell-cell adhesion and acquisition of the mesenchymal phenotype."xsd:string |
| http://purl.uniprot.org/citations/18799618 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e08-05-0506"xsd:string |
| http://purl.uniprot.org/citations/18799618 | http://purl.uniprot.org/core/author | "Olsen B.R."xsd:string |
| http://purl.uniprot.org/citations/18799618 | http://purl.uniprot.org/core/author | "Medici D."xsd:string |
| http://purl.uniprot.org/citations/18799618 | http://purl.uniprot.org/core/author | "Hay E.D."xsd:string |
| http://purl.uniprot.org/citations/18799618 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18799618 | http://purl.uniprot.org/core/name | "Mol Biol Cell"xsd:string |
| http://purl.uniprot.org/citations/18799618 | http://purl.uniprot.org/core/pages | "4875-4887"xsd:string |
| http://purl.uniprot.org/citations/18799618 | http://purl.uniprot.org/core/title | "Snail and Slug promote epithelial-mesenchymal transition through beta-catenin-T-cell factor-4-dependent expression of transforming growth factor-beta3."xsd:string |
| http://purl.uniprot.org/citations/18799618 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/18799618 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18799618 |
| http://purl.uniprot.org/citations/18799618 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18799618 |
| http://purl.uniprot.org/uniprot/#_A0A0D9SGH8-mappedCitation-18799618 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18799618 |
| http://purl.uniprot.org/uniprot/#_A0A0A0MTL7-mappedCitation-18799618 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18799618 |
| http://purl.uniprot.org/uniprot/#_E2GH26-mappedCitation-18799618 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18799618 |
| http://purl.uniprot.org/uniprot/#_B3KVH9-mappedCitation-18799618 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18799618 |
| http://purl.uniprot.org/uniprot/#_A0A994J711-mappedCitation-18799618 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18799618 |
| http://purl.uniprot.org/uniprot/#_A0A2Z5HTM8-mappedCitation-18799618 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18799618 |
| http://purl.uniprot.org/uniprot/#_A0A2Z5HTN9-mappedCitation-18799618 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18799618 |
| http://purl.uniprot.org/uniprot/#_B4DJZ2-mappedCitation-18799618 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18799618 |
| http://purl.uniprot.org/uniprot/#_B4DSW9-mappedCitation-18799618 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18799618 |
| http://purl.uniprot.org/uniprot/#_B2ZRE2-mappedCitation-18799618 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18799618 |
| http://purl.uniprot.org/uniprot/#_B2ZRG2-mappedCitation-18799618 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18799618 |
| http://purl.uniprot.org/uniprot/#_B4DGU4-mappedCitation-18799618 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18799618 |