| http://purl.uniprot.org/citations/18802068 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18802068 | http://www.w3.org/2000/01/rdf-schema#comment | "Nonalcoholic steatohepatitis (NASH), the most common cause of chronic liver fibrosis, progresses to cirrhosis in up to 20% of patients. We report that hepatic stellate cells (HSC) in sinusoidal lesions of liver of patients with NASH express high levels of high-affinity IL-13R (IL-13Ralpha2), which is colocalized with smooth muscle actin, whereas fatty liver and normal liver specimens do not express IL-13Ralpha2. HSCs engineered to overexpress IL-13Ralpha2 respond to IL-13 and induce TGFB1 promoter activity and TGF-beta1 production. We also developed NASH in rats by feeding a choline-deficient l-amino acid diet. These rats developed liver fibrosis as assessed by H&E staining, Masson's trichrome and Sirius red staining, and hydroxyproline assays. Treatment of these rats with IL-13R-directed cytotoxin caused a substantial decline in fibrosis and liver enzymes without organ toxicity. These studies demonstrate that functional IL-13Ralpha2 are overexpressed in activated HSCs involved in NASH and that IL-13 cytotoxin ameliorates pathological features of NASH in rat liver, indicating a novel role of this cytotoxin in potential therapy."xsd:string |
| http://purl.uniprot.org/citations/18802068 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.181.7.4656"xsd:string |
| http://purl.uniprot.org/citations/18802068 | http://purl.uniprot.org/core/author | "Fujisawa T."xsd:string |
| http://purl.uniprot.org/citations/18802068 | http://purl.uniprot.org/core/author | "Shimamura T."xsd:string |
| http://purl.uniprot.org/citations/18802068 | http://purl.uniprot.org/core/author | "Nakajima A."xsd:string |
| http://purl.uniprot.org/citations/18802068 | http://purl.uniprot.org/core/author | "Puri R.K."xsd:string |
| http://purl.uniprot.org/citations/18802068 | http://purl.uniprot.org/core/author | "Kioi M."xsd:string |
| http://purl.uniprot.org/citations/18802068 | http://purl.uniprot.org/core/author | "Husain S.R."xsd:string |
| http://purl.uniprot.org/citations/18802068 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18802068 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/18802068 | http://purl.uniprot.org/core/pages | "4656-4665"xsd:string |
| http://purl.uniprot.org/citations/18802068 | http://purl.uniprot.org/core/title | "Novel role of IL-13 in fibrosis induced by nonalcoholic steatohepatitis and its amelioration by IL-13R-directed cytotoxin in a rat model."xsd:string |
| http://purl.uniprot.org/citations/18802068 | http://purl.uniprot.org/core/volume | "181"xsd:string |
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