| http://purl.uniprot.org/citations/18803939 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18803939 | http://www.w3.org/2000/01/rdf-schema#comment | "Pancreatic carboxyl ester lipase (CEL) is in the plasma of many mammals, including humans and rats, but not mice. In vitro, CEL hydrolyzes cholesterol esters of apolipoprotein B-containing lipoproteins (apo B-Lp). To study the effect of CEL on metabolism of apo B-Lp and atherosclerosis in vivo, apo E-knockout (EKO) mice, which have high plasma levels of apo B-Lp and are prone to atherosclerosis, were made to secrete CEL into plasma by introducing a transgene containing a liver-specific promoter and rat CEL complementary DNA. Plasma CEL activity in EKO-CEL mice was comparable with that found in rats. Evidence of modification of apo B-Lp by plasma CEL in vivo was an increase in the free cholesterol to cholesterol ester ratio of apo B-Lp from mice on chow or a Western-type diet. In addition, plasma total cholesterol levels were elevated in EKO-CEL mice, with the elevation found exclusively in the apo B-Lp fraction. Associated with the increase in steady-state apo B-Lp levels was an increase in the plasma half-life of very low-density lipoproteins (VLDL) in EKO-CEL mice, measured by the clearance rate of injected VLDL. Interestingly, despite the increase of apo B-Lp, the atherosclerotic lesion did not differ between EKO and EKO-CEL mice on a Western-type diet. In summary, our results demonstrate that plasma CEL modulates apo B-Lp metabolism in vivo, resulting in reduced VLDL clearance and elevated plasma cholesterol levels."xsd:string |
| http://purl.uniprot.org/citations/18803939 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.metabol.2008.05.003"xsd:string |
| http://purl.uniprot.org/citations/18803939 | http://purl.uniprot.org/core/author | "Li L."xsd:string |
| http://purl.uniprot.org/citations/18803939 | http://purl.uniprot.org/core/author | "Weng W."xsd:string |
| http://purl.uniprot.org/citations/18803939 | http://purl.uniprot.org/core/author | "Fisher E.A."xsd:string |
| http://purl.uniprot.org/citations/18803939 | http://purl.uniprot.org/core/author | "Harrison E.H."xsd:string |
| http://purl.uniprot.org/citations/18803939 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18803939 | http://purl.uniprot.org/core/name | "Metabolism"xsd:string |
| http://purl.uniprot.org/citations/18803939 | http://purl.uniprot.org/core/pages | "1361-1368"xsd:string |
| http://purl.uniprot.org/citations/18803939 | http://purl.uniprot.org/core/title | "Plasma carboxyl ester lipase activity modulates apolipoprotein B-containing lipoprotein metabolism in a transgenic mouse model."xsd:string |
| http://purl.uniprot.org/citations/18803939 | http://purl.uniprot.org/core/volume | "57"xsd:string |
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