| http://purl.uniprot.org/citations/18806787 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18806787 | http://www.w3.org/2000/01/rdf-schema#comment | "The von Hippel-Lindau protein pVHL suppresses renal tumorigenesis in part by promoting the degradation of hypoxia-inducible HIF-alpha transcription factors; additional mechanisms have been proposed. pVHL also stabilizes the plant homeodomain protein Jade-1, which is a candidate renal tumour suppressor that may correlate with renal cancer risk. Here we show that Jade-1 binds the oncoprotein beta-catenin in Wnt-responsive fashion. Moreover, Jade-1 destabilizes wild-type beta-catenin but not a cancer-causing form of beta-catenin. Whereas the well-established beta-catenin E3 ubiquitin ligase component beta-TrCP ubiquitylates only phosphorylated beta-catenin, Jade-1 ubiquitylates both phosphorylated and non-phosphorylated beta-catenin and therefore regulates canonical Wnt signalling in both Wnt-off and Wnt-on phases. Thus, the different characteristics of beta-TrCP and Jade-1 may ensure optimal Wnt pathway regulation. Furthermore, pVHL downregulates beta-catenin in a Jade-1-dependent manner and inhibits Wnt signalling, supporting a role for Jade-1 and Wnt signalling in renal tumorigenesis. The pVHL tumour suppressor and the Wnt tumorigenesis pathway are therefore directly linked through Jade-1."xsd:string |
| http://purl.uniprot.org/citations/18806787 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb1781"xsd:string |
| http://purl.uniprot.org/citations/18806787 | http://purl.uniprot.org/core/author | "Bharti A."xsd:string |
| http://purl.uniprot.org/citations/18806787 | http://purl.uniprot.org/core/author | "Zeng L."xsd:string |
| http://purl.uniprot.org/citations/18806787 | http://purl.uniprot.org/core/author | "Seldin D.C."xsd:string |
| http://purl.uniprot.org/citations/18806787 | http://purl.uniprot.org/core/author | "Dominguez I."xsd:string |
| http://purl.uniprot.org/citations/18806787 | http://purl.uniprot.org/core/author | "Lecker S.H."xsd:string |
| http://purl.uniprot.org/citations/18806787 | http://purl.uniprot.org/core/author | "Chitalia V.C."xsd:string |
| http://purl.uniprot.org/citations/18806787 | http://purl.uniprot.org/core/author | "Cohen H.T."xsd:string |
| http://purl.uniprot.org/citations/18806787 | http://purl.uniprot.org/core/author | "Foy R.L."xsd:string |
| http://purl.uniprot.org/citations/18806787 | http://purl.uniprot.org/core/author | "Panchenko M.V."xsd:string |
| http://purl.uniprot.org/citations/18806787 | http://purl.uniprot.org/core/author | "Zhou M.I."xsd:string |
| http://purl.uniprot.org/citations/18806787 | http://purl.uniprot.org/core/author | "Bachschmid M.M."xsd:string |
| http://purl.uniprot.org/citations/18806787 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18806787 | http://purl.uniprot.org/core/name | "Nat Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/18806787 | http://purl.uniprot.org/core/pages | "1208-1216"xsd:string |
| http://purl.uniprot.org/citations/18806787 | http://purl.uniprot.org/core/title | "Jade-1 inhibits Wnt signalling by ubiquitylating beta-catenin and mediates Wnt pathway inhibition by pVHL."xsd:string |
| http://purl.uniprot.org/citations/18806787 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/18806787 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18806787 |
| http://purl.uniprot.org/citations/18806787 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18806787 |
| http://purl.uniprot.org/uniprot/#_A0A024R2F2-mappedCitation-18806787 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18806787 |
| http://purl.uniprot.org/uniprot/#_A4ZYX2-mappedCitation-18806787 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18806787 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z4K1-mappedCitation-18806787 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18806787 |
| http://purl.uniprot.org/uniprot/#_B4DSW9-mappedCitation-18806787 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18806787 |