| http://purl.uniprot.org/citations/18807071 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18807071 | http://www.w3.org/2000/01/rdf-schema#comment | "PTL-1, a microtubule-associated protein of the structural MAP2/tau family, is the sole member of this gene family in Caenorhabditis elegans. Sequence analysis of available invertebrate genomes revealed a number of single, putative tau-like genes with high similarity to ptl-1. The ptl-1 gene is expressed in a number of cells, most notably mechanosensory neurons. We examined the role of ptl-1 in C. elegans in adult neurons as well as during development. A ptl-1 knockout strain of worms exhibited an egg-hatching defect, as well as a reduced sensitivity to touch stimuli. In addition, the knockout allele ptl-1(ok621) acts as a dominant enhancer of several temperature-sensitive alleles of mec-7 and mec-12, which code the isoforms of beta-tubulin and alpha-tubulin that together form the unusual 15 protofilament microtubules involved in touch sensation. These results demonstrate for the first time a functional role for this microtubule-associated protein in nematodes and suggest that PTL-1 is involved in mechanosensation as well as some aspect of embryogenesis."xsd:string |
| http://purl.uniprot.org/citations/18807071 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00427-008-0250-z"xsd:string |
| http://purl.uniprot.org/citations/18807071 | http://purl.uniprot.org/core/author | "Gordon P."xsd:string |
| http://purl.uniprot.org/citations/18807071 | http://purl.uniprot.org/core/author | "Pokrywka N.J."xsd:string |
| http://purl.uniprot.org/citations/18807071 | http://purl.uniprot.org/core/author | "Hingula L."xsd:string |
| http://purl.uniprot.org/citations/18807071 | http://purl.uniprot.org/core/author | "Krasny M.L."xsd:string |
| http://purl.uniprot.org/citations/18807071 | http://purl.uniprot.org/core/author | "Raley-Susman K.M."xsd:string |
| http://purl.uniprot.org/citations/18807071 | http://purl.uniprot.org/core/author | "Swienckowski J.L."xsd:string |
| http://purl.uniprot.org/citations/18807071 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18807071 | http://purl.uniprot.org/core/name | "Dev Genes Evol"xsd:string |
| http://purl.uniprot.org/citations/18807071 | http://purl.uniprot.org/core/pages | "541-551"xsd:string |
| http://purl.uniprot.org/citations/18807071 | http://purl.uniprot.org/core/title | "The invertebrate microtubule-associated protein PTL-1 functions in mechanosensation and development in Caenorhabditis elegans."xsd:string |
| http://purl.uniprot.org/citations/18807071 | http://purl.uniprot.org/core/volume | "218"xsd:string |
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