| http://purl.uniprot.org/citations/18815158 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18815158 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18815158 | http://www.w3.org/2000/01/rdf-schema#comment | "Two GPR39 transcripts, designated as sbGPR39-1a and sbGPR39-1b, were identified in black seabream (Acanthopagrus schlegeli). The deduced amino acid (aa) sequence of sbGPR39-1a contains 423 residues with seven putative transmembrane (TM) domains. On the other hand, sbGPR39-1b contains 284 aa residues with only five putative TM domains. Northern blot analysis confirmed the presence of two GPR39 transcripts in the seabream intestine, stomach, and liver. Apart from seabream, the presence of two GPR39 transcripts was also found to exist in a number of teleosts (zebrafish and pufferfish) and mammals (human and mouse). Analysis of the GPR39 gene structure in different species suggests that the two GPR39 transcripts are generated by alternative splicing. When the seabream receptors were expressed in cultured HEK293 cells, Zn(2)(+) could trigger sbGPR39-1a signaling through the serum response element pathway, but no such functionality could be detected for the sbGPR39-1b receptor. The two receptors were found to be differentially expressed in seabream tissues. sbGPR39-1a is predominantly expressed in the gastrointestinal tract. On the other hand, sbGPR39-1b is widely expressed in most central and peripheral tissues except muscle and ovary. The expression of sbGPR39-1a in the intestine and the expression of sbGPR39-1b in the hypothalamus were decreased significantly during food deprivation in seabream. On the contrary, the expression of the GH secretagogue receptors (sbGHSR-1a and sbGHSR-1b) was significantly increased in the hypothalamus of the food-deprived seabream. The reciprocal regulatory patterns of expression of these two genes suggest that both of them are involved in controlling the physiological response of the organism during starvation."xsd:string |
| http://purl.uniprot.org/citations/18815158 | http://purl.org/dc/terms/identifier | "doi:10.1677/JOE-07-0608"xsd:string |
| http://purl.uniprot.org/citations/18815158 | http://purl.org/dc/terms/identifier | "doi:10.1677/joe-07-0608"xsd:string |
| http://purl.uniprot.org/citations/18815158 | http://purl.uniprot.org/core/author | "Huang X."xsd:string |
| http://purl.uniprot.org/citations/18815158 | http://purl.uniprot.org/core/author | "Huang X."xsd:string |
| http://purl.uniprot.org/citations/18815158 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/18815158 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/18815158 | http://purl.uniprot.org/core/author | "Li S."xsd:string |
| http://purl.uniprot.org/citations/18815158 | http://purl.uniprot.org/core/author | "Li S."xsd:string |
| http://purl.uniprot.org/citations/18815158 | http://purl.uniprot.org/core/author | "Liu X."xsd:string |
| http://purl.uniprot.org/citations/18815158 | http://purl.uniprot.org/core/author | "Liu X."xsd:string |
| http://purl.uniprot.org/citations/18815158 | http://purl.uniprot.org/core/author | "Lin H."xsd:string |
| http://purl.uniprot.org/citations/18815158 | http://purl.uniprot.org/core/author | "Lin H."xsd:string |
| http://purl.uniprot.org/citations/18815158 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/18815158 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/18815158 | http://purl.uniprot.org/core/author | "Zhu P."xsd:string |
| http://purl.uniprot.org/citations/18815158 | http://purl.uniprot.org/core/author | "Zhu P."xsd:string |
| http://purl.uniprot.org/citations/18815158 | http://purl.uniprot.org/core/author | "Meng Z."xsd:string |
| http://purl.uniprot.org/citations/18815158 | http://purl.uniprot.org/core/author | "Meng Z."xsd:string |
| http://purl.uniprot.org/citations/18815158 | http://purl.uniprot.org/core/author | "Cheng C.H."xsd:string |
| http://purl.uniprot.org/citations/18815158 | http://purl.uniprot.org/core/author | "Cheng C.H."xsd:string |
| http://purl.uniprot.org/citations/18815158 | http://purl.uniprot.org/core/author | "Jiao B."xsd:string |
| http://purl.uniprot.org/citations/18815158 | http://purl.uniprot.org/core/author | "Jiao B."xsd:string |