| http://purl.uniprot.org/citations/18815286 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18815286 | http://www.w3.org/2000/01/rdf-schema#comment | "CD44, the leukocyte adhesion receptor for hyaluronan, has been considered a therapeutic target on the basis of the robust anti-inflammatory effect of CD44-specific antibodies in animal models of immune-mediated diseases. However, CD44 deficiency does not provide substantial protection against inflammation. Using intravital video microscopy in a murine model of rheumatoid arthritis, we show that CD44 deficiency and anti-CD44 antibody treatment exert disparate effects on leukocyte recruitment in inflamed joints. Leukocyte rolling, which is increased in CD44-deficient mice, is promptly abrogated in anti-CD44-treated wild-type mice. CD44-specific antibodies also trigger platelet deposition on granulocytes and subsequent depletion of this leukocyte subset in the circulation. These in vivo effects require CD44 cross-linking and are reproducible with an antibody against Gr-1, a molecule that, like CD44, is highly expressed on granulocytes. Anticoagulant pretreatment, which prevents platelet deposition, mitigates both granulocyte depletion and the suppressive effect of CD44-specific antibody on joint swelling. Our observations suggest that cross-linking of prominent cell surface molecules, such as CD44 or Gr-1, can initiate a rapid self-elimination program in granulocytes through engagement of the coagulation system. We conclude that the robust anti-inflammatory effect of CD44-specific antibodies in arthritis is primarily the result of their ability to trigger granulocyte depletion."xsd:string |
| http://purl.uniprot.org/citations/18815286 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2008-04-150383"xsd:string |
| http://purl.uniprot.org/citations/18815286 | http://purl.uniprot.org/core/author | "Finnegan A."xsd:string |
| http://purl.uniprot.org/citations/18815286 | http://purl.uniprot.org/core/author | "Gal I."xsd:string |
| http://purl.uniprot.org/citations/18815286 | http://purl.uniprot.org/core/author | "Glant T.T."xsd:string |
| http://purl.uniprot.org/citations/18815286 | http://purl.uniprot.org/core/author | "Mikecz K."xsd:string |
| http://purl.uniprot.org/citations/18815286 | http://purl.uniprot.org/core/author | "Bajnok E."xsd:string |
| http://purl.uniprot.org/citations/18815286 | http://purl.uniprot.org/core/author | "Hutas G."xsd:string |
| http://purl.uniprot.org/citations/18815286 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18815286 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/18815286 | http://purl.uniprot.org/core/pages | "4999-5006"xsd:string |
| http://purl.uniprot.org/citations/18815286 | http://purl.uniprot.org/core/title | "CD44-specific antibody treatment and CD44 deficiency exert distinct effects on leukocyte recruitment in experimental arthritis."xsd:string |
| http://purl.uniprot.org/citations/18815286 | http://purl.uniprot.org/core/volume | "112"xsd:string |
| http://purl.uniprot.org/citations/18815286 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18815286 |
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