| http://purl.uniprot.org/citations/18819930 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18819930 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18819930 | http://www.w3.org/2000/01/rdf-schema#comment | "The presence of somatic beta-catenin mutations in some prostate cancers implies that aberrant WNT signaling is involved in the cancer development. Although beta-catenin stability is regulated by a multicomponent destruction complex, mutational alterations of beta-catenin or other components of the destruction complexes are rare in prostate tumors. Therefore, beta-catenin may be regulated by another protein in the prostate. In fact, recent linkage and somatic deletion analyses in prostate cancers reveal a 1.4-Mb candidate tumor suppressor locus on 8p23.1, which includes the Sox7 gene. Here we show that Sox7 protein expression was indeed down-regulated in 47% (15 of 32) of prostate adenocarcinomas. In addition, Sox7 mRNA was down-regulated in 60% of snap-frozen tumors. This down-regulation was found to be due to tumor-specific promoter hypermethylation, which was present in 48% (10 of 21) of primary prostate tumors and 44% (11 of 25) of prostate cancer cell lines/xenografts. We discovered that Sox7 protein physically interacts with beta-catenin and suppresses beta-catenin-mediated transcription by depleting active beta-catenin. Furthermore, in HCT116 colorectal cancer cell lines with Sox7 inactivation, ectopic Sox7 expression suppressed cell proliferation and inhibited transcription that was activated by an endogenous mutant beta-catenin. Although nearly all colorectal cancers contain mutations in beta-catenin or adenomatous polyposis coli/axin, epigenetic silencing of Sox7 was still observed. These data suggest that Sox7 is a tumor suppressor that functions as an independent checkpoint for beta-catenin transcriptional activity. Inactivation of Sox7 could promote the development of a majority of colorectal tumors and approximately half of prostate tumors."xsd:string |
| http://purl.uniprot.org/citations/18819930 | http://purl.org/dc/terms/identifier | "doi:10.1158/1541-7786.mcr-07-2175"xsd:string |
| http://purl.uniprot.org/citations/18819930 | http://purl.org/dc/terms/identifier | "doi:10.1158/1541-7786.mcr-07-2175"xsd:string |
| http://purl.uniprot.org/citations/18819930 | http://purl.uniprot.org/core/author | "Guo L."xsd:string |
| http://purl.uniprot.org/citations/18819930 | http://purl.uniprot.org/core/author | "Guo L."xsd:string |
| http://purl.uniprot.org/citations/18819930 | http://purl.uniprot.org/core/author | "Liu X."xsd:string |
| http://purl.uniprot.org/citations/18819930 | http://purl.uniprot.org/core/author | "Liu X."xsd:string |
| http://purl.uniprot.org/citations/18819930 | http://purl.uniprot.org/core/author | "Sun X."xsd:string |
| http://purl.uniprot.org/citations/18819930 | http://purl.uniprot.org/core/author | "Sun X."xsd:string |
| http://purl.uniprot.org/citations/18819930 | http://purl.uniprot.org/core/author | "Zhou W."xsd:string |
| http://purl.uniprot.org/citations/18819930 | http://purl.uniprot.org/core/author | "Zhou W."xsd:string |
| http://purl.uniprot.org/citations/18819930 | http://purl.uniprot.org/core/author | "Yang V.W."xsd:string |
| http://purl.uniprot.org/citations/18819930 | http://purl.uniprot.org/core/author | "Yang V.W."xsd:string |
| http://purl.uniprot.org/citations/18819930 | http://purl.uniprot.org/core/author | "Zhong D."xsd:string |
| http://purl.uniprot.org/citations/18819930 | http://purl.uniprot.org/core/author | "Zhong D."xsd:string |
| http://purl.uniprot.org/citations/18819930 | http://purl.uniprot.org/core/author | "Dong X.Y."xsd:string |
| http://purl.uniprot.org/citations/18819930 | http://purl.uniprot.org/core/author | "Dong X.Y."xsd:string |
| http://purl.uniprot.org/citations/18819930 | http://purl.uniprot.org/core/author | "Lau S."xsd:string |
| http://purl.uniprot.org/citations/18819930 | http://purl.uniprot.org/core/author | "Lau S."xsd:string |
| http://purl.uniprot.org/citations/18819930 | http://purl.uniprot.org/core/author | "Vertino P.M."xsd:string |
| http://purl.uniprot.org/citations/18819930 | http://purl.uniprot.org/core/author | "Vertino P.M."xsd:string |
| http://purl.uniprot.org/citations/18819930 | http://purl.uniprot.org/core/author | "Dong J.T."xsd:string |
| http://purl.uniprot.org/citations/18819930 | http://purl.uniprot.org/core/author | "Dong J.T."xsd:string |