| http://purl.uniprot.org/citations/18820371 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18820371 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundThere are very few studies on the final triggers of apoptosis, the caspases, in breast cancer.Materials and methodsCaspase-3 expression was studied by means of reverse transcript polymerase chain reaction (RT-PCR) in a series of 108 previously untreated patients with breast cancer. Expression levels were correlated with those obtained using the same technique of the apoptosis-associated X-chromosome genes RBMX, RBM3, RBM10 small and RBM10 large variant; Bcl-2 and Bax; the angiogenesis-associated genes VEGF and CD105 (endoglin); hMAM and Nup88. The correlation with the expression of hormone receptors, c-erb-B2, mutant p53 and Ki-67, all measured by means of immunohistochemistry, was also studied, as well as that with standard clinical parameters such as histological type, tumor size, axillary metastasis and DNA-ploidy.ResultsThe only statistically significant correlations observed between caspase-3 mRNA expression and the parameters tested were a direct one with both the Bax (p = 0.007) and the small variant of the X-chromosome RBM10 gene (p = 0.018), and an inverse one with the angiogenesis-associated CD105 (endoglin) gene (p = 0.044).ConclusionThese results indicate that very few genes are involved in the last steps of the apoptotic cascade in breast cancer, among them one of the X-chromosome RBM family. They also support the relatively unexplored link between apoptosis and angiogenesis."xsd:string |
| http://purl.uniprot.org/citations/18820371 | http://purl.uniprot.org/core/author | "Martinez-Arribas F."xsd:string |
| http://purl.uniprot.org/citations/18820371 | http://purl.uniprot.org/core/author | "Schneider J."xsd:string |
| http://purl.uniprot.org/citations/18820371 | http://purl.uniprot.org/core/author | "Sanchez J."xsd:string |
| http://purl.uniprot.org/citations/18820371 | http://purl.uniprot.org/core/author | "Pollan M."xsd:string |
| http://purl.uniprot.org/citations/18820371 | http://purl.uniprot.org/core/author | "Lucas A.R."xsd:string |
| http://purl.uniprot.org/citations/18820371 | http://purl.uniprot.org/core/author | "Martin-Garabato E."xsd:string |
| http://purl.uniprot.org/citations/18820371 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18820371 | http://purl.uniprot.org/core/name | "Cancer Genomics Proteomics"xsd:string |
| http://purl.uniprot.org/citations/18820371 | http://purl.uniprot.org/core/pages | "169-173"xsd:string |
| http://purl.uniprot.org/citations/18820371 | http://purl.uniprot.org/core/title | "The small variant of the apoptosis-associated X-chromosome RBM10 gene is co-expressed with caspase-3 in breast cancer."xsd:string |
| http://purl.uniprot.org/citations/18820371 | http://purl.uniprot.org/core/volume | "5"xsd:string |
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