| http://purl.uniprot.org/citations/18821589 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18821589 | http://www.w3.org/2000/01/rdf-schema#comment | "We generated a transgenic mouse strain (LSL-TbetaRI(CA)) containing a latent constitutively active TGFbeta type I receptor (TbetaRI/ALK5) by using a knock-in strategy into the X chromosome-linked hypoxanthine phosphoribosyl-transferase (Hprt) locus. Transgene expression, under the control of the ubiquitous CAG (human cytomegalovirus enhancer and chicken beta-actin) promoter, is repressed by a floxed transcriptional "Stop" (LSL, Lox-Stop-Lox). In the presence of cre-recombinase, the "Stop" is excised to allow TbetaRI(CA) transgene expression. We showed that restricted expression of TbetaRI(CA) in T lymphocytes efficiently activates TGFbeta signaling and rescues the T-cell autoimmune disorders of TGFbetaRII conditional knockouts. Unexpectedly, our study reveals that TGFbeta signaling upregulation controls T-cell activation but does not impair their development or their peripheral homeostasis. In addition to the information provided on TGFbeta effects on T-cell biology, LSL-TbetaRI(CA) mouse constitutes an attractive tool to address the effect of TGFbeta signaling upregulation in any cell type expressing the cre-recombinase."xsd:string |
| http://purl.uniprot.org/citations/18821589 | http://purl.org/dc/terms/identifier | "doi:10.1002/dvg.20425"xsd:string |
| http://purl.uniprot.org/citations/18821589 | http://purl.uniprot.org/core/author | "Vincent D."xsd:string |
| http://purl.uniprot.org/citations/18821589 | http://purl.uniprot.org/core/author | "Bartholin L."xsd:string |
| http://purl.uniprot.org/citations/18821589 | http://purl.uniprot.org/core/author | "Martel S."xsd:string |
| http://purl.uniprot.org/citations/18821589 | http://purl.uniprot.org/core/author | "Rimokh R."xsd:string |
| http://purl.uniprot.org/citations/18821589 | http://purl.uniprot.org/core/author | "Marie J.C."xsd:string |
| http://purl.uniprot.org/citations/18821589 | http://purl.uniprot.org/core/author | "Treilleux I."xsd:string |
| http://purl.uniprot.org/citations/18821589 | http://purl.uniprot.org/core/author | "Horvat B."xsd:string |
| http://purl.uniprot.org/citations/18821589 | http://purl.uniprot.org/core/author | "Berthet C."xsd:string |
| http://purl.uniprot.org/citations/18821589 | http://purl.uniprot.org/core/author | "Garcia C.N."xsd:string |
| http://purl.uniprot.org/citations/18821589 | http://purl.uniprot.org/core/author | "Goddard-Leon S."xsd:string |
| http://purl.uniprot.org/citations/18821589 | http://purl.uniprot.org/core/author | "Cyprian F.S."xsd:string |
| http://purl.uniprot.org/citations/18821589 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18821589 | http://purl.uniprot.org/core/name | "Genesis"xsd:string |
| http://purl.uniprot.org/citations/18821589 | http://purl.uniprot.org/core/pages | "724-731"xsd:string |
| http://purl.uniprot.org/citations/18821589 | http://purl.uniprot.org/core/title | "Generation of mice with conditionally activated transforming growth factor beta signaling through the TbetaRI/ALK5 receptor."xsd:string |
| http://purl.uniprot.org/citations/18821589 | http://purl.uniprot.org/core/volume | "46"xsd:string |
| http://purl.uniprot.org/citations/18821589 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18821589 |
| http://purl.uniprot.org/citations/18821589 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18821589 |
| http://purl.uniprot.org/uniprot/#_E9Q6I6-mappedCitation-18821589 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18821589 |
| http://purl.uniprot.org/uniprot/#_E9Q418-mappedCitation-18821589 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18821589 |
| http://purl.uniprot.org/uniprot/#_P04202-mappedCitation-18821589 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18821589 |
| http://purl.uniprot.org/uniprot/#_Q62312-mappedCitation-18821589 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18821589 |