| http://purl.uniprot.org/citations/18824516 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18824516 | http://www.w3.org/2000/01/rdf-schema#comment | "Production of aberrant messenger ribonucleoprotein particles (mRNPs) is subject to quality control (QC). In yeast strains carrying mutations of the THO complex, transcription induction triggers a number of interconnected QC phenotypes: (1) rapid degradation of several mRNAs; (2) retention of a fraction of THO-dependent mRNAs in transcription site-associated foci; and (3) formation of a high molecular weight DNA/protein complex in the 3'-ends of THO target genes. Here, we demonstrate that the 3'-5' exonucleolytic domain of the nuclear exosome factor Rrp6p is necessary for establishing all QC phenotypes associated with THO mutations. The N terminus of Rrp6p is also important presumably through its binding to the Rrp6p co-factor Rrp47p. Interestingly, the 3'-5' exonucleolytic activity of Dis3p, the only other active exonuclease of the nuclear exosome, can also contribute to RNA QC in THO mutants, while other nuclear 3'-5' exonucleases cannot. Our data show that exonucleolytic attack by the nuclear exosome is needed both for provoking mRNP QC and for its ensuing elimination of faulty RNA."xsd:string |
| http://purl.uniprot.org/citations/18824516 | http://purl.org/dc/terms/identifier | "doi:10.1261/rna.1108008"xsd:string |
| http://purl.uniprot.org/citations/18824516 | http://purl.uniprot.org/core/author | "Andersen K.R."xsd:string |
| http://purl.uniprot.org/citations/18824516 | http://purl.uniprot.org/core/author | "Libri D."xsd:string |
| http://purl.uniprot.org/citations/18824516 | http://purl.uniprot.org/core/author | "Brodersen D.E."xsd:string |
| http://purl.uniprot.org/citations/18824516 | http://purl.uniprot.org/core/author | "Mouaikel J."xsd:string |
| http://purl.uniprot.org/citations/18824516 | http://purl.uniprot.org/core/author | "Jensen T.H."xsd:string |
| http://purl.uniprot.org/citations/18824516 | http://purl.uniprot.org/core/author | "Assenholt J."xsd:string |
| http://purl.uniprot.org/citations/18824516 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18824516 | http://purl.uniprot.org/core/name | "RNA"xsd:string |
| http://purl.uniprot.org/citations/18824516 | http://purl.uniprot.org/core/pages | "2305-2313"xsd:string |
| http://purl.uniprot.org/citations/18824516 | http://purl.uniprot.org/core/title | "Exonucleolysis is required for nuclear mRNA quality control in yeast THO mutants."xsd:string |
| http://purl.uniprot.org/citations/18824516 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/18824516 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18824516 |
| http://purl.uniprot.org/citations/18824516 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18824516 |
| http://purl.uniprot.org/uniprot/#_Q08162-mappedCitation-18824516 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18824516 |
| http://purl.uniprot.org/uniprot/#_Q12149-mappedCitation-18824516 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18824516 |
| http://purl.uniprot.org/uniprot/Q08162 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18824516 |
| http://purl.uniprot.org/uniprot/Q12149 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18824516 |