| http://purl.uniprot.org/citations/18824542 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18824542 | http://www.w3.org/2000/01/rdf-schema#comment | "Glycogen synthase kinase 3beta (GSK-3beta) represses cell cycle progression by directly phosphorylating cyclin D1 and indirectly regulating cyclin D1 transcription by inhibiting Wnt signaling. Recently, we reported that the Epm2a-encoded laforin is a GSK-3beta phosphatase and a tumor suppressor. The cellular mechanism for its tumor suppression remains unknown. Using ex vivo thymocytes and primary embryonic fibroblasts from Epm2a(-/-) mice, we show here a general function of laforin in the cell cycle regulation and repression of cyclin D1 expression. Moreover, targeted mutation of Epm2a increased the phosphorylation of Ser9 on GSK-3beta while having no effect on the phosphorylation of Ser21 on GSK-3alpha. In the GSK-3beta(+/+) but not the GSK-3beta(-/-) cells, Epm2a small interfering RNA significantly enhanced cell growth. Consistent with an increased level of cyclin D1, the phosphorylation of retinoblastoma protein (Rb) and the levels of Rb-E2F-regulated genes cyclin A, cyclin E, MCM3, and PCNA are also elevated. Inhibitors of GSK-3beta selectively increased the cell growth of Epm2a(+/+) but not of Epm2a(-/-) cells. Taken together, our data demonstrate that laforin is a selective phosphatase for GSK-3beta and regulates cell cycle progression by GSK-3beta-dependent mechanisms. These data provide a cellular basis for the tumor suppression activity of laforin."xsd:string |
| http://purl.uniprot.org/citations/18824542 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.01334-08"xsd:string |
| http://purl.uniprot.org/citations/18824542 | http://purl.uniprot.org/core/author | "Chen C."xsd:string |
| http://purl.uniprot.org/citations/18824542 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/18824542 | http://purl.uniprot.org/core/author | "Liu R."xsd:string |
| http://purl.uniprot.org/citations/18824542 | http://purl.uniprot.org/core/author | "Liu Y.'"xsd:string |
| http://purl.uniprot.org/citations/18824542 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/18824542 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/18824542 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/18824542 | http://purl.uniprot.org/core/author | "Zheng P."xsd:string |
| http://purl.uniprot.org/citations/18824542 | http://purl.uniprot.org/core/author | "Zhou P."xsd:string |
| http://purl.uniprot.org/citations/18824542 | http://purl.uniprot.org/core/author | "Minassian B.A."xsd:string |
| http://purl.uniprot.org/citations/18824542 | http://purl.uniprot.org/core/author | "Turnbull J."xsd:string |
| http://purl.uniprot.org/citations/18824542 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18824542 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/18824542 | http://purl.uniprot.org/core/pages | "7236-7244"xsd:string |
| http://purl.uniprot.org/citations/18824542 | http://purl.uniprot.org/core/title | "Laforin negatively regulates cell cycle progression through glycogen synthase kinase 3beta-dependent mechanisms."xsd:string |
| http://purl.uniprot.org/citations/18824542 | http://purl.uniprot.org/core/volume | "28"xsd:string |
| http://purl.uniprot.org/citations/18824542 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18824542 |
| http://purl.uniprot.org/citations/18824542 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18824542 |
| http://purl.uniprot.org/uniprot/Q9WUA5#attribution-360CB3043852F483F8D65F729D127E9F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18824542 |
| http://purl.uniprot.org/uniprot/Q9WV60#attribution-360CB3043852F483F8D65F729D127E9F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18824542 |
| http://purl.uniprot.org/uniprot/#_A0A338P6P8-mappedCitation-18824542 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18824542 |
| http://purl.uniprot.org/uniprot/#_E9QAQ5-mappedCitation-18824542 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18824542 |