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http://purl.uniprot.org/citations/18824844http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/18824844http://www.w3.org/2000/01/rdf-schema#comment"

Background

Hepatocyte growth factor (HGF) is overexpressed after acute kidney injury (AKI). The aim of this study was to evaluate the role of endogenous HGF in the progression of the inflammatory response in glycerol-induced AKI (Gly-AKI) in rats.

Methods

Renal and systemic HGF expressions were evaluated during the development of Gly-AKI. Subsequently, the blockade of endogenous HGF was analyzed in rats treated with anti-HGF antibody concomitant to glycerol injection. Apoptosis, cell infiltration and chemokine and cytokine profiles were investigated.

Results

We detected an early peak of renal and plasma HGF protein expressions 3 h after glycerol injection. The pharmacological blockade of the endogenous HGF exacerbated the renal impairment, the tubular apoptosis, the renal expression of monocyte chemoattractant protein-1 and the macrophage, CD43+, CD4+ and CD8+ T lymphocytes renal infiltration. The analysis of mRNA expressions of Th1 (t-bet, TNF-alpha, IL-1beta) and Th2 (gata-3, IL-4, IL-10) cytokines showed a Th1-polarized response in Gly-AKI rats that was aggravated with the anti-HGF treatment.

Conclusion

Endogenous HGF attenuates the renal inflammatory response, leukocyte infiltration and Th1 polarization after glycerol injection. The control of cellular immune response may partly explain the protective effect of endogenous HGF in the development of Gly-AKI."xsd:string
http://purl.uniprot.org/citations/18824844http://purl.org/dc/terms/identifier"doi:10.1159/000159275"xsd:string
http://purl.uniprot.org/citations/18824844http://purl.uniprot.org/core/author"Amano M."xsd:string
http://purl.uniprot.org/citations/18824844http://purl.uniprot.org/core/author"Homsi E."xsd:string
http://purl.uniprot.org/citations/18824844http://purl.uniprot.org/core/author"Janino P."xsd:string
http://purl.uniprot.org/citations/18824844http://purl.uniprot.org/core/author"Saraiva Camara N.O."xsd:string
http://purl.uniprot.org/citations/18824844http://purl.uniprot.org/core/date"2009"xsd:gYear
http://purl.uniprot.org/citations/18824844http://purl.uniprot.org/core/name"Am J Nephrol"xsd:string
http://purl.uniprot.org/citations/18824844http://purl.uniprot.org/core/pages"283-291"xsd:string
http://purl.uniprot.org/citations/18824844http://purl.uniprot.org/core/title"Endogenous hepatocyte growth factor attenuates inflammatory response in glycerol-induced acute kidney injury."xsd:string
http://purl.uniprot.org/citations/18824844http://purl.uniprot.org/core/volume"29"xsd:string
http://purl.uniprot.org/citations/18824844http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/18824844
http://purl.uniprot.org/citations/18824844http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/18824844
http://purl.uniprot.org/uniprot/#_A6K5E8-mappedCitation-18824844http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18824844
http://purl.uniprot.org/uniprot/#_A6K5E9-mappedCitation-18824844http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18824844
http://purl.uniprot.org/uniprot/#_P17945-mappedCitation-18824844http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18824844
http://purl.uniprot.org/uniprot/A6K5E9http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/18824844
http://purl.uniprot.org/uniprot/A6K5E8http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/18824844
http://purl.uniprot.org/uniprot/P17945http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/18824844