| http://purl.uniprot.org/citations/18827027 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18827027 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18827027 | http://www.w3.org/2000/01/rdf-schema#comment | "Human cytidine deaminase apolipoprotein B mRNA-editing catalytic polypeptide-like 3 (APOBEC3) proteins have been classified as either Z1- or Z2-type cytidine deaminases on the basis of phylogenetic analysis of their catalytic domains. Despite the identification of a number of Z1-type domain-containing cytidine deaminases, only one copy of Z2-type cytidine deaminase has been detected in each of the mammalian species evaluated thus far. Z1-type human APOBEC3 proteins are known to exhibit broad activities against diverse retroelements. However, the potential role of the only human Z2-type cytidine deaminase, APOBEC3H (A3H), in the restriction of retroelements has not yet been fully characterized. Here, we demonstrate that human A3H is a potent inhibitor of non-LTR LINE-1 transposition. Interestingly, it was also as efficient as A3G in inhibiting Alu retrotransposition, despite its poor association with Alu RNA. We have further demonstrated, for the first time, that human APOBEC3DE is also a potent inhibitor of Alu retrotransposition. Variants of A3H have divergent antiviral activities against HIV-1-Vif-deficient viruses. Unlike the anti-HIV-1 cytidine deaminases A3G and A3F, A3H is moderately regulated by interferons. These observations suggest that human Z2-type cytidine deaminase A3H variants have varying intrinsic abilities to restrict retroelements and that various APOBEC3 proteins may have evolved distinct inhibitory mechanisms against retroelements."xsd:string |
| http://purl.uniprot.org/citations/18827027 | http://purl.org/dc/terms/identifier | "doi:10.1096/fj.07-088781"xsd:string |
| http://purl.uniprot.org/citations/18827027 | http://purl.org/dc/terms/identifier | "doi:10.1096/fj.07-088781"xsd:string |
| http://purl.uniprot.org/citations/18827027 | http://purl.uniprot.org/core/author | "Wang T."xsd:string |
| http://purl.uniprot.org/citations/18827027 | http://purl.uniprot.org/core/author | "Wang T."xsd:string |
| http://purl.uniprot.org/citations/18827027 | http://purl.uniprot.org/core/author | "Tian C."xsd:string |
| http://purl.uniprot.org/citations/18827027 | http://purl.uniprot.org/core/author | "Tian C."xsd:string |
| http://purl.uniprot.org/citations/18827027 | http://purl.uniprot.org/core/author | "Tan L."xsd:string |
| http://purl.uniprot.org/citations/18827027 | http://purl.uniprot.org/core/author | "Tan L."xsd:string |
| http://purl.uniprot.org/citations/18827027 | http://purl.uniprot.org/core/author | "Sarkis P.T."xsd:string |
| http://purl.uniprot.org/citations/18827027 | http://purl.uniprot.org/core/author | "Sarkis P.T."xsd:string |
| http://purl.uniprot.org/citations/18827027 | http://purl.uniprot.org/core/author | "Yu X.F."xsd:string |
| http://purl.uniprot.org/citations/18827027 | http://purl.uniprot.org/core/author | "Yu X.F."xsd:string |
| http://purl.uniprot.org/citations/18827027 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/18827027 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/18827027 | http://purl.uniprot.org/core/name | "FASEB J."xsd:string |
| http://purl.uniprot.org/citations/18827027 | http://purl.uniprot.org/core/name | "FASEB J."xsd:string |
| http://purl.uniprot.org/citations/18827027 | http://purl.uniprot.org/core/pages | "279-287"xsd:string |
| http://purl.uniprot.org/citations/18827027 | http://purl.uniprot.org/core/pages | "279-287"xsd:string |
| http://purl.uniprot.org/citations/18827027 | http://purl.uniprot.org/core/title | "Sole copy of Z2-type human cytidine deaminase APOBEC3H has inhibitory activity against retrotransposons and HIV-1."xsd:string |
| http://purl.uniprot.org/citations/18827027 | http://purl.uniprot.org/core/title | "Sole copy of Z2-type human cytidine deaminase APOBEC3H has inhibitory activity against retrotransposons and HIV-1."xsd:string |
| http://purl.uniprot.org/citations/18827027 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/18827027 | http://purl.uniprot.org/core/volume | "23"xsd:string |